Ex-Vivo Reversion of Platelet Inhibition Induced by Prasugrel

This study has been completed.
Information provided by (Responsible Party):
Fanny Bonhomme, University Hospital, Geneva
ClinicalTrials.gov Identifier:
First received: April 22, 2013
Last updated: August 18, 2014
Last verified: August 2014

The purpose of this ex-vivo study is to estimate the optimal platelet quantity necessary to reverse the antiplatelet effects of prasugrel.

Condition Intervention
Acquired Platelet Disorder
Other: Ex vivo addition of normal platelet rich plasma to prasugrel-treated platelet rich plasma

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by University Hospital, Geneva:

Primary Outcome Measures:
  • Platelet reactivity assessed by light transmittance aggregometry (LTA) after ex-vivo normal platelet addition [ Time Frame: within the first 6-24 hours after antiplatelet drug loading dose ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA


Enrollment: 32
Study Start Date: September 2011
Study Completion Date: January 2014
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Study patients
Acute coronary syndrome patients with a recent loading dose of prasugrel (6-24h)
Other: Ex vivo addition of normal platelet rich plasma to prasugrel-treated platelet rich plasma


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with acute coronary syndrome who received a loading dose of prasugrel within 6 and 24h.


Inclusion Criteria:

  • Acute coronary syndrome
  • Prasugrel loading dose 6-24h before inclusion

Exclusion Criteria:

  • Clopidogrel loading dose
  • GPIIbIIIa use within 10 days before inclusion
  • Known congenital thrombopathy and/or congenital coagulation defect
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01839968

University Hospital of Geneva
Geneva, GE, Switzerland, 1205
Sponsors and Collaborators
University Hospital, Geneva
  More Information

No publications provided

Responsible Party: Fanny Bonhomme, MD, University Hospital, Geneva
ClinicalTrials.gov Identifier: NCT01839968     History of Changes
Other Study ID Numbers: 11-117
Study First Received: April 22, 2013
Last Updated: August 18, 2014
Health Authority: Switzerland: Swissmedic

Additional relevant MeSH terms:
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Pharmacologic Actions
Physiological Effects of Drugs
Purinergic Agents
Purinergic Antagonists
Purinergic P2 Receptor Antagonists
Purinergic P2Y Receptor Antagonists

ClinicalTrials.gov processed this record on March 30, 2015