Ex-Vivo Reversion of Platelet Inhibition Induced by Prasugrel

This study has been completed.
Information provided by (Responsible Party):
Fanny Bonhomme, University Hospital, Geneva
ClinicalTrials.gov Identifier:
First received: April 22, 2013
Last updated: August 18, 2014
Last verified: August 2014
The purpose of this ex-vivo study is to estimate the optimal platelet quantity necessary to reverse the antiplatelet effects of prasugrel.

Condition Intervention
Acquired Platelet Disorder
Other: Ex vivo addition of normal platelet rich plasma to prasugrel-treated platelet rich plasma

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by University Hospital, Geneva:

Primary Outcome Measures:
  • Platelet reactivity assessed by light transmittance aggregometry (LTA) after ex-vivo normal platelet addition [ Time Frame: within the first 6-24 hours after antiplatelet drug loading dose ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Enrollment: 32
Study Start Date: September 2011
Study Completion Date: January 2014
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Study patients
Acute coronary syndrome patients with a recent loading dose of prasugrel (6-24h)
Other: Ex vivo addition of normal platelet rich plasma to prasugrel-treated platelet rich plasma


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with acute coronary syndrome who received a loading dose of prasugrel within 6 and 24h.

Inclusion Criteria:

  • Acute coronary syndrome
  • Prasugrel loading dose 6-24h before inclusion

Exclusion Criteria:

  • Clopidogrel loading dose
  • GPIIbIIIa use within 10 days before inclusion
  • Known congenital thrombopathy and/or congenital coagulation defect
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01839968

University Hospital of Geneva
Geneva, GE, Switzerland, 1205
Sponsors and Collaborators
University Hospital, Geneva
  More Information

Responsible Party: Fanny Bonhomme, MD, University Hospital, Geneva
ClinicalTrials.gov Identifier: NCT01839968     History of Changes
Other Study ID Numbers: 11-117 
Study First Received: April 22, 2013
Last Updated: August 18, 2014
Health Authority: Switzerland: Swissmedic

Additional relevant MeSH terms:
Blood Platelet Disorders
Hematologic Diseases

ClinicalTrials.gov processed this record on May 23, 2016