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Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis

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ClinicalTrials.gov Identifier: NCT01839006
Recruitment Status : Completed
First Posted : April 24, 2013
Last Update Posted : April 24, 2013
Sponsor:
Information provided by (Responsible Party):
Sung Yong Cho, Seoul National University Hospital

Brief Summary:
The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (> 55%) in the DTPA renography will be analyzed.

Condition or disease Intervention/treatment
Hydronephrosis Procedure: dismembered pyeloplasty

Detailed Description:
To assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (> 55%) in the DTPA renography will be analyzed. Clinical parameters including age at the first visit, age at operation, gender, laterality, and follow-up period will be evaluated. To evaluate predictors of recovery from supranormal renal function according to the level of DRF, univariate and multivariate logistic regression analyses will be performed. Patients would be subcategorized into two groups; group A (DRF ≤60%) and group B (DRF >60%) in consideration of the mean value of preoperative DRF and each parameter of group A was compared to that of group B using independent sample's t test and chi square test. Kaplan-Meier analysis and log-rank test will be used to determine the difference of recovery time of obstructed hydronephrosis in each parameter.

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Study Type : Observational
Actual Enrollment : 34 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Clinical Significance of Supranormal Differential Renal Function in the Recovery of Unilateral Hydronephrosis After Surgery: Long-term Results
Study Start Date : June 2011
Actual Primary Completion Date : June 2011
Actual Study Completion Date : June 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Tests

Group/Cohort Intervention/treatment
patients with supranormal renal function
Patients with preoperative HN and supranormal renal function in DTPA renography
Procedure: dismembered pyeloplasty
Using a flank approach, as the patient was placed in the lateral decubitus position, and an anterior subcostal incision was made. The narrow segment of UPJ was identified and resected, and then the proximal edge of the ureter was spatulated to allow a wide anastomosis between the ureter and the most dependent part of the renal pelvis. The extent of renal pelvis reduction was decided by the surgeon.




Primary Outcome Measures :
  1. Hydronephrosis [ Time Frame: postop 6 months ]
    The grade of hydronephrosis would be check at 6 months postoperatively.


Secondary Outcome Measures :
  1. renal parenchymal thickness [ Time Frame: postop 6 months ]
    Renal parenchymal thickness was measured.



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Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with unilateral UPJO pediatric patients who underwent dismembered pyeloplasty and preoperative HN in USG and supranormal renal function in DTPA renography
Criteria

Inclusion Criteria:

  • ureteropelvic junction obstruction
  • hydronephrosis
  • differential renal function more than 55% in DTPA
  • follow-up period more than 1 year

Exclusion Criteria:

  • urological anomalies, such as vesicoureteral reflux, ureterocele, cystic kidney disease, posterior urethral valves, duplex anomalies, neurogenic bladder, and solitary kidney or patients who underwent any previous urological surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01839006


Locations
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Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Seoul National University Hospital
Investigators
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Principal Investigator: Sung Yong Cho, M.D. Seoul National Universitiy Hospital
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Responsible Party: Sung Yong Cho, Seoul National University Hospital
ClinicalTrials.gov Identifier: NCT01839006    
Other Study ID Numbers: supranormal
supranormal DRF
First Posted: April 24, 2013    Key Record Dates
Last Update Posted: April 24, 2013
Last Verified: April 2013
Keywords provided by Sung Yong Cho, Seoul National University Hospital:
hydronephrosis
ultrasonography
Kidney Function Test
Patients with unilateral UPJO and patients with preop HN in USG and supranormal renal function in DTPA renography
Additional relevant MeSH terms:
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Hydronephrosis
Kidney Diseases
Urologic Diseases