We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov Menu

Inhalation of Lidocaine Before Intubation

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2013 by Chen Yen-Po, New Taipei City Hospital.
Recruitment status was:  Recruiting
ClinicalTrials.gov Identifier:
First Posted: April 24, 2013
Last Update Posted: April 24, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Chen Yen-Po, New Taipei City Hospital
We investigate the potential benefits of ultrasound-driven lidocaine inhalation immediately before induction.

Condition Intervention
Sore Throat Drug: Lidocaine inhalation Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: The Effect of Ultrasonic Nebulizer Delivered Lidocaine on Circulatory Responses During Tracheal Intubation and Postoperative Sore Throat

Resource links provided by NLM:

Further study details as provided by Chen Yen-Po, New Taipei City Hospital:

Primary Outcome Measures:
  • Blood pressure [ Time Frame: 3 min ]
    Non invasive blood pressure every min for 3 min

Secondary Outcome Measures:
  • Post operative sore throat [ Time Frame: 3 days ]
    Questionnaire for Post operative sore throat

Estimated Enrollment: 70
Study Start Date: January 2013
Estimated Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Lidocaine
Inhalation of lidocaine before intubation
Drug: Lidocaine inhalation
Lidocaine inhalation before intubation
Placebo Comparator: Control
Normal saline inhalation before intubation
Drug: Placebo

Detailed Description:
Sudden increases in blood pressure and heart rate after tracheal intubation and post-operative sore throat are two common undesirable side effects of general anesthesia and might lead to patients' morbidity or dissatisfaction. We investigated the possibility to attenuate both side effects with one single method, i.e. ultrasound-driven lidocaine inhalation immediately before induction.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • American Society of Anesthesiologists (ASA) physical status I or II. Patients scheduled for elective surgery under general anesthesia with orotracheal intubation

Exclusion Criteria:

  • patient's refusal to join, major surgery or expected operation duration longer than 3 hours, patients with a anticipated difficult airway, requiring a nasogastric tube in peri-operative stage, having recent upper respiratory tract infection (within 1 week) or pre-existing sore throat.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01838993

Contact: Chen Yen Po, MD drbrianchan@yahoo.com.tw

New Taipei City Hospital Recruiting
New Taipei City, Taiwan
Contact: Lin Chi-Hsuan, MD       ad2354@ntpc.gov.tw   
Sponsors and Collaborators
New Taipei City Hospital
Principal Investigator: Chen Yen Po, MD New Taipei City Hospital
  More Information

Responsible Party: Chen Yen-Po, Physician, New Taipei City Hospital
ClinicalTrials.gov Identifier: NCT01838993     History of Changes
Other Study ID Numbers: CS 2013011
First Submitted: April 21, 2013
First Posted: April 24, 2013
Last Update Posted: April 24, 2013
Last Verified: April 2013

Keywords provided by Chen Yen-Po, New Taipei City Hospital:
nebulizers and vaporizers;

Additional relevant MeSH terms:
Pharyngeal Diseases
Stomatognathic Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Anti-Arrhythmia Agents
Voltage-Gated Sodium Channel Blockers
Sodium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action