Inhalation of Lidocaine Before Intubation

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2013 by New Taipei City Hospital.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
Chen Yen-Po, New Taipei City Hospital Identifier:
First received: April 21, 2013
Last updated: April 23, 2013
Last verified: April 2013
We investigate the potential benefits of ultrasound-driven lidocaine inhalation immediately before induction.

Condition Intervention
Sore Throat
Drug: Lidocaine inhalation
Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: The Effect of Ultrasonic Nebulizer Delivered Lidocaine on Circulatory Responses During Tracheal Intubation and Postoperative Sore Throat

Resource links provided by NLM:

Further study details as provided by New Taipei City Hospital:

Primary Outcome Measures:
  • Blood pressure [ Time Frame: 3 min ] [ Designated as safety issue: No ]
    Non invasive blood pressure every min for 3 min

Secondary Outcome Measures:
  • Post operative sore throat [ Time Frame: 3 days ] [ Designated as safety issue: No ]
    Questionnaire for Post operative sore throat

Estimated Enrollment: 70
Study Start Date: January 2013
Estimated Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Lidocaine
Inhalation of lidocaine before intubation
Drug: Lidocaine inhalation
Lidocaine inhalation before intubation
Placebo Comparator: Control
Normal saline inhalation before intubation
Drug: Placebo

Detailed Description:
Sudden increases in blood pressure and heart rate after tracheal intubation and post-operative sore throat are two common undesirable side effects of general anesthesia and might lead to patients' morbidity or dissatisfaction. We investigated the possibility to attenuate both side effects with one single method, i.e. ultrasound-driven lidocaine inhalation immediately before induction.

Ages Eligible for Study:   20 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • American Society of Anesthesiologists (ASA) physical status I or II. Patients scheduled for elective surgery under general anesthesia with orotracheal intubation

Exclusion Criteria:

  • patient's refusal to join, major surgery or expected operation duration longer than 3 hours, patients with a anticipated difficult airway, requiring a nasogastric tube in peri-operative stage, having recent upper respiratory tract infection (within 1 week) or pre-existing sore throat.
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Please refer to this study by its identifier: NCT01838993

Contact: Chen Yen Po, MD

New Taipei City Hospital Recruiting
New Taipei City, Taiwan
Contact: Lin Chi-Hsuan, MD   
Sponsors and Collaborators
New Taipei City Hospital
Principal Investigator: Chen Yen Po, MD New Taipei City Hospital
  More Information

No publications provided

Responsible Party: Chen Yen-Po, Physician, New Taipei City Hospital Identifier: NCT01838993     History of Changes
Other Study ID Numbers: CS 2013011
Study First Received: April 21, 2013
Last Updated: April 23, 2013
Health Authority: Taiwan: Department of Health

Keywords provided by New Taipei City Hospital:
nebulizers and vaporizers;

Additional relevant MeSH terms:
Otorhinolaryngologic Diseases
Pharyngeal Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Stomatognathic Diseases
Anesthetics, Local
Anti-Arrhythmia Agents
Cardiovascular Agents
Central Nervous System Agents
Central Nervous System Depressants
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sensory System Agents
Sodium Channel Blockers
Therapeutic Uses
Voltage-Gated Sodium Channel Blockers processed this record on November 27, 2015