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Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft (NOAHS)

This study has been completed.
Information provided by (Responsible Party):
Yale University Identifier:
First received: April 15, 2013
Last updated: February 3, 2017
Last verified: February 2017

The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery.

The main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-CABG depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.

Intracranial Atherosclerosis
Coronary Artery Disease

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Intracranial Atherosclerosis and Predictors of Post-CABG Depression

Resource links provided by NLM:

Further study details as provided by Yale University:

Primary Outcome Measures:
  • Pre-surgical intracranial atherosclerosis as measured by transcranial doppler ultrasound relative to depressive symptoms post-surgically as measured by DISH. [ Time Frame: 12 months ]

Secondary Outcome Measures:
  • Examine neurocognitive function relative to post-CABG depression through a series of neurocognitive tests. [ Time Frame: 12 months ]
    Neurocognitive tests are aimed at evaluating memory, processing speed, and global cognition.

Enrollment: 169
Study Start Date: September 2012
Primary Completion Date: August 2016 (Final data collection date for primary outcome measure)
No treatment.


Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study population for this study will be drawn from cardiac surgery patients at a university-based hospital who will undergo coronary artery bypass graft (CABG) surgery.

Inclusion Criteria:

  • Age: 40 years or older
  • Will be having CABG surgery at the Yale New Haven Hospital
  • Be able to provide informed consent
  • Have a household telephone
  • A fluent English speaker, and possessing no communication barrier
  • Be able to come to the study site or to have the study team come to his/her home.
  • Has a family member or partner/ friend who could provide collateral information

Exclusion Criteria:

  • Has had previous CABG surgery
  • History of dementia diagnosis or cognitive impairment (CDR >/= 1)
  • Auditory or visual impairment that would interfere with study procedures
  • Active alcohol or substance abuse problem based CAGE-AID (endorsing two or more items)
  • History of Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, or any Psychotic Disorder by medical history or self-report.
  • Presence of non-cardiovascular conditions likely to be fatal within 1 year
  Contacts and Locations
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Please refer to this study by its identifier: NCT01838356

United States, Connecticut
Yale University School of Medicine
New Haven, Connecticut, United States, 06510
United States, Maryland
The Johns Hopkins University
Baltimore, Maryland, United States, 21218
Sponsors and Collaborators
Yale University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Yale University Identifier: NCT01838356     History of Changes
Other Study ID Numbers: MH085740
Study First Received: April 15, 2013
Last Updated: February 3, 2017

Keywords provided by Yale University:
Vascular depression
Intracranial atherosclerosis
Coronary artery disease
Coronary artery bypass graft
Cognitive impairment

Additional relevant MeSH terms:
Depressive Disorder
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Intracranial Arteriosclerosis
Behavioral Symptoms
Mood Disorders
Mental Disorders
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Intracranial Arterial Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases processed this record on April 28, 2017