Respirophasic Carotid Artery Peak Velocity Variation as a Predictor of Fluid Responsiveness in Patients With Coronary Disease
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ClinicalTrials.gov Identifier: NCT01836081 |
Recruitment Status
:
Completed
First Posted
: April 19, 2013
Last Update Posted
: April 19, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Coronary Artery Occlusive Disease | Other: Volume expansion | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 40 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Diagnostic |
Study Start Date : | December 2011 |
Actual Primary Completion Date : | December 2012 |
Actual Study Completion Date : | December 2012 |

Arm | Intervention/treatment |
---|---|
Experimental: fluid responsiveness |
Other: Volume expansion
Other Name: volume expansion with 6 mL/kg of 6% hydroxylethyl starch 130/0.4
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- Predictive power of the respirophasic carotid flow peak velocity variation for the fluid responsiveness [ Time Frame: Measurement of respirophasic carotid flow peak velocity variation before the volume expansion ]After induction of anesthesia, peak velocity of carotid artery blood flow is measured by the pulsed wave Doppler signal obtained from the left common carotid artery. Respirophasic variation of the peak velocity is defined as the difference between the maximum and the minimum values of peak velocity divided by the mean of the two values during one respiratory cycle. Fluid responder is defined as a patient whose stroke volume index is increased ≥15% after volume expansion. The receiver operating characteristic curve analysis to descriminiate fluid responder is performed.

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Ages Eligible for Study: | 20 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
1. patients scheduled for elective isolated off-pump coronary artery bypass graft surgery
Exclusion Criteria:
- cardiac rhythm other than sinus
- congestive heart failure
- left ventricular ejection fraction <35%
- history of transient ischemic attack
- pre-existing cerebrovascular disease and peripheral arterial occlusive disease
- presence of carotid artery stenosis >50%

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01836081
Korea, Republic of | |
Yonsei University College of Medicine | |
Seoul, Korea, Republic of, 120-752 |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Yonsei University |
ClinicalTrials.gov Identifier: | NCT01836081 History of Changes |
Other Study ID Numbers: |
4-2011-0687 |
First Posted: | April 19, 2013 Key Record Dates |
Last Update Posted: | April 19, 2013 |
Last Verified: | April 2013 |
Keywords provided by Yonsei University:
fluid responsiveness carotid artery peak velocity variation coronary disease |
Additional relevant MeSH terms:
Coronary Disease Myocardial Ischemia Heart Diseases Cardiovascular Diseases Vascular Diseases |