Effect of Tetrabenazine on Stroop Interference in HD
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|ClinicalTrials.gov Identifier: NCT01834911|
Recruitment Status : Completed
First Posted : April 18, 2013
Last Update Posted : April 2, 2018
|Condition or disease||Intervention/treatment||Phase|
|Huntington Disease||Drug: Tetrabenazine withdrawal||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||2 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Tetrabenazine on Stroop Interference in Huntington Disease|
|Actual Study Start Date :||March 2013|
|Actual Primary Completion Date :||January 1, 2018|
|Actual Study Completion Date :||January 1, 2018|
Experimental: Tetrabenazine withdrawal
Tetrabenazine will be withdrawn for at least 3 days in Huntington disease patients currently taking the medication.
Drug: Tetrabenazine withdrawal
Tetrabenazine will be withdrawn for at least 3 days in Huntington disease patients currently on the drug. Patients will be examined via Stroop test in the OFF state. Two doses of 12.5 mg tetrabenazine will be introduced, spaced 3 hours apart. Stroop test will be performed 6 hours after initial OFF Stroop test.
- Change in Stroop Interference Score [ Time Frame: 6 hours ]Participants will have Stroop Visual Interference Scores measured while OFF tetrabenazine for at least 3 days. Two doses of 12.5 mg tetrabenazine will be subsequently administered: first dose just after the Stroop test and second dose 3 hours later. Stroop Visual Interference Scores will be measured again in the ON state, 6 hours after the initial OFF measurement.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01834911
|United States, New York|
|Terence Cardinal Cooke Health Care Center|
|New York, New York, United States, 10029|