Autonomic Dysfunction in Resistant Hypertension (RH)
The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.
Hypertension, Resistant to Conventional Therapy
|Study Type:||Observational [Patient Registry]|
|Study Design:||Observational Model: Cohort|
|Target Follow-Up Duration:||10 Months|
|Official Title:||Circadian Autonomic Disturbances in Resistant Hypertension With and Without White-coat Phenomenon|
- evaluation of the autonomic function in resistant hypertensive patients [ Time Frame: 10 months ] [ Designated as safety issue: No ]
The autonomic nervous system can be assessed by the heart rate variability. Variations in heart rate variability are normally observed in association with diurnal rhythms and blood pressure changes. The heart rate variability parameters are different in many studies, although the consensus is that lower values of the indices of vagal as well as high indices of sympathetic functions are associated prospectively with death and disability.
In humans, the disturbances of the circadian rhythms of heart rate variability and blood pressure have been intensively studied, mainly due to the increased cardiovascular death reported during the morning hours
|Study Start Date:||September 2011|
|Study Completion Date:||December 2012|
|Primary Completion Date:||November 2012 (Final data collection date for primary outcome measure)|
The current definition of resistant hypertension (RH) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications and those whose BP is controlled when using four or more antihypertensive medications
All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.
Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01833429
|Cardiovascular Pharmacology Laboratory|
|Campinas, Sao Paulo, Brazil, 13083-888|