Lactic Acidosis During and After Seizures
This project looks at the time course of lactic acid rise (if any) after seizures. Salivary and capillary lactic acid are tested. This type of measurement may be useful in signalling the occurrence or recent history of a seizure.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
- Significant increase of blood and salivary lactic acid [ Time Frame: Within 10 minutes of end of the seizure ] [ Designated as safety issue: No ]The investigators will assess the time course of lactic acid change after a seizure. Values will consist of lactic acid measurements in blood and saliva with baseline (pre-seizure), immediately post-seizure, then at 30 mins and 2 hours. Units of measurement will be mM/L. A positive outcome will be a curve different from a straight line, with a rise and fall of lactate levels. Baseline lactate serum level is expected to be less than 2.2 mM/L. A useful outcome of this study will be identification of lactic acid above 4.4 mM/L (more than doubling) within 5 minutes of a seizure, occurring in at least half of the subjects.
- Salivary and capillary lactic acid will be correlated after a seizure [ Time Frame: Within 10 minutes of a seizure ] [ Designated as safety issue: No ]Salivary levels of lactic acid is being studied because saliva is more accessible in the outpatient setting than is blood. Concentration of lactic acid in the serum and saliva from each individual subject will be correlated using Pearson's correlation test. We will consider a positive outcome to be a r greater than or equal to 0.5 and significance at p<0.05.
|Study Start Date:||July 2012|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Patients with epilepsy recorded in an inpatient video-EEG monitoring unit after a seizure.
|Other: Measurement of lactic acid with a seizure|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01833247
|United States, California|
|Stanford, California, United States, 94305-5235|