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Adiponectin and Ethnic Differences in Insulin Resistance

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ClinicalTrials.gov Identifier: NCT01831102
Recruitment Status : Completed
First Posted : April 15, 2013
Last Update Posted : April 15, 2013
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.

Condition or disease Intervention/treatment
Insulin Resistance Type 2 Diabetes Other: none- observational study

Study Design

Study Type : Observational
Actual Enrollment : 43 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Adiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance
Study Start Date : March 2011
Primary Completion Date : August 2011
Study Completion Date : August 2011

Resource links provided by the National Library of Medicine

Drug Information available for: Insulin
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
non-Latino white
no Latino ancestry, Caucasian
Other: none- observational study
Mexican American
Mexican American ancestry
Other: none- observational study


Outcome Measures

Primary Outcome Measures :
  1. total adiponectin concentration [ Time Frame: measured once during second study visit, in fasting condition ]

Secondary Outcome Measures :
  1. Insulin sensitivity [ Time Frame: Measured once, during second study visit. ]
    Calculated from insulin and glucose values obtained during IV glucose tolerance test.


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample
Criteria

Inclusion Criteria:

  • 18-60 years of age
  • BMI 20.0-34.9 m/kg2
  • Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

Exclusion Criteria:

  • pregnancy
  • breastfeeding
  • diabetes mellitus
  • blood pressure > 160/100 mmHg
  • creatinine > 1.5 mg/dl or glomerular filtration rate (GFR) < 60
  • liver function tests > 3x upper limit of normal (ULN)
  • h/o heart failure
  • h/o eating disorder
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01831102


Locations
United States, Colorado
University of Colorado Anschutz Medical Center
Aurora, Colorado, United States, 80045
Sponsors and Collaborators
University of Colorado, Denver
Investigators
Principal Investigator: Rocio Pereira, MD University of Colorado, Denver
More Information

Responsible Party: University of Colorado, Denver
ClinicalTrials.gov Identifier: NCT01831102     History of Changes
Other Study ID Numbers: 10-1260
First Posted: April 15, 2013    Key Record Dates
Last Update Posted: April 15, 2013
Last Verified: April 2013

Keywords provided by University of Colorado, Denver:
insulin resistance
ethnic disparities
adiponectin

Additional relevant MeSH terms:
Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs