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Adiponectin and Ethnic Differences in Insulin Resistance

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01831102
First Posted: April 15, 2013
Last Update Posted: April 15, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Colorado, Denver
  Purpose
The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.

Condition Intervention
Insulin Resistance Type 2 Diabetes Other: none- observational study

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Adiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance

Resource links provided by NLM:


Further study details as provided by University of Colorado, Denver:

Primary Outcome Measures:
  • total adiponectin concentration [ Time Frame: measured once during second study visit, in fasting condition ]

Secondary Outcome Measures:
  • Insulin sensitivity [ Time Frame: Measured once, during second study visit. ]
    Calculated from insulin and glucose values obtained during IV glucose tolerance test.


Enrollment: 43
Study Start Date: March 2011
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
non-Latino white
no Latino ancestry, Caucasian
Other: none- observational study
Mexican American
Mexican American ancestry
Other: none- observational study

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample
Criteria

Inclusion Criteria:

  • 18-60 years of age
  • BMI 20.0-34.9 m/kg2
  • Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

Exclusion Criteria:

  • pregnancy
  • breastfeeding
  • diabetes mellitus
  • blood pressure > 160/100 mmHg
  • creatinine > 1.5 mg/dl or glomerular filtration rate (GFR) < 60
  • liver function tests > 3x upper limit of normal (ULN)
  • h/o heart failure
  • h/o eating disorder
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01831102


Locations
United States, Colorado
University of Colorado Anschutz Medical Center
Aurora, Colorado, United States, 80045
Sponsors and Collaborators
University of Colorado, Denver
Investigators
Principal Investigator: Rocio Pereira, MD University of Colorado, Denver
  More Information

Responsible Party: University of Colorado, Denver
ClinicalTrials.gov Identifier: NCT01831102     History of Changes
Other Study ID Numbers: 10-1260
First Submitted: April 5, 2013
First Posted: April 15, 2013
Last Update Posted: April 15, 2013
Last Verified: April 2013

Keywords provided by University of Colorado, Denver:
insulin resistance
ethnic disparities
adiponectin

Additional relevant MeSH terms:
Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs