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Differential Plasma MicroRNA Profiles in ED and Normal Erectile Function in Older Males

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ClinicalTrials.gov Identifier: NCT01830049
Recruitment Status : Unknown
Verified April 2013 by Feng Pan, Nanjing Medical University.
Recruitment status was:  Recruiting
First Posted : April 11, 2013
Last Update Posted : April 11, 2013
Sponsor:
Information provided by (Responsible Party):
Feng Pan, Nanjing Medical University

Brief Summary:
Erectile dysfunction (ED) is strongly associated with aging. With the rapidly expanding aging population and the increase in life expectancy, an increase in the prevalence of ED is expected in the years to come. Currently, the mechanism of ED is not fully understood. MicroRNAs (MiRNA) are endogenous small RNA molecules that control gene expression post-transcriptionally. It has been included in many in vitro physiology and pathophysiology processes, which also involved in the process of ED. This research was designed to investigate the differential plasma MiRNA profiles in ED and normal erectile function in older males. The results might tell us which MiRNA and how did it involved in the process of ED in aging.

Condition or disease Intervention/treatment
Erectile Dysfunction Other: Take blood

Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Study Start Date : March 2013
Estimated Primary Completion Date : July 2013
Estimated Study Completion Date : August 2013

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort Intervention/treatment
Group I
Older males with ED
Other: Take blood
Group II
Older males with normal erectile function
Other: Take blood
Gourp III
Young males with normal rectile function
Other: Take blood



Primary Outcome Measures :
  1. Gene chips [ Time Frame: 30 days ]

Secondary Outcome Measures :
  1. RT-PCR [ Time Frame: 15 days ]


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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Group I: older males came to our clinic for diagnosis and treatment of ED. Group II: older males came to our clinic for physical examination and the erectile function was normal.

Group III: young males came to our clinic for physical examination and the erectile function was normal.

Criteria

Inclusion Criteria:

  • older males with erectile dysfunction

Exclusion Criteria:

  • have some other general diseases, e.g. hypertension, vascular diseases, depression, chronic kidney disease, diabetes.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01830049


Contacts
Contact: Feng Pan, Doctor 0086-25-52226379 panfeng27@yahoo.com.cn

Locations
China, Jiangsu
Nanjing Gulou Hospital affiliated to Nanjing University, Medical School Recruiting
Nanjing, Jiangsu, China, 210000
Contact: Yutian Dai, Doctor    0086-25-52227777      
Sponsors and Collaborators
Nanjing Medical University

Responsible Party: Feng Pan, MD., Nanjing Medical University
ClinicalTrials.gov Identifier: NCT01830049     History of Changes
Other Study ID Numbers: NJU2013024
2013024 ( Other Identifier: Nanjing University, Medical School )
First Posted: April 11, 2013    Key Record Dates
Last Update Posted: April 11, 2013
Last Verified: April 2013

Additional relevant MeSH terms:
Erectile Dysfunction
Sexual Dysfunction, Physiological
Genital Diseases, Male
Sexual Dysfunctions, Psychological
Mental Disorders