Efficacy and Safety of Βeta-adrenoceptor Inverse Agonist and Biased Ligand, Nadolol, In Smoking Cessation of Patients With Chronic Cough With or Without Airflow Obstruction
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To test the hypothesis that treatment with the inverse agonist nadolol will improve smoking cessation in patients with chronic cough associated with long-term smoking, with or without airflow obstruction, including those with established chronic obstructive pulmonary disease (COPD) (chronic bronchitis dominant) or non-obstructive chronic bronchitis (NCB), compared to placebo and standard of care, while undergoing a validated smoking cessation program.
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Ages Eligible for Study:
18 Years to 70 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Potential study participants will be referred from approved smoking cessation programs or be willing to enter a smoking cessation program administered by the participating sites. Individuals who meet all of the following criteria at Visit 1 are eligible for enrollment as study participants:
Active cigarette-smoking males and females between the ages of 18-70 with chronic cough associated with long-term smoking, with or without airflow obstruction, including Non-obstructive chronic bronchitis (NCB) or physician-diagnosed COPD (chronic bronchitis dominant), as defined by the American Thoracic Society.
Committed desire to quit smoking in conjunction with participation in an approved smoking cessation program administered by the participating sites. Enrollment in the smoking cessation program must take place prior to Visit 3 (third dose escalation visit).
Diagnosis of COPD (chronic bronchitis dominant) or NCB, or presenting with chronic cough associated with long-term smoking.
Pre-bronchodilator FEV1 greater than 55% of predicted
Baseline blood pressure ≥ 110/65mm Hg
Baseline heart rate ≥ 60 beats/min.
Smoking at least 10 cigarettes per day prior to participation in the approved smoking cessation program.
Self-reported prior failure(s) to quit smoking during participation in a smoking cessation program.
Able to complete diary cards and comply with study procedures.
Females of childbearing age may participate only if they have a negative pregnancy test, are non-lactating, and agree to practice an adequate birth control method (abstinence, combination barrier and spermicide, or hormonal) for the duration of the study.
Subjects who meet ANY of the following criteria are not eligible for enrollment:
Diagnosis of asthma, cystic fibrosis, or PiZZ emphysema
Inability or unwillingness to give written informed consent
History of upper/lower respiratory tract infection, COPD exacerbation requiring systemic steroids, antibiotics, and or ER visit or urgent care within 6 weeks of Visit 1
History of adverse reaction or allergy to nadolol
History of neurological, hepatic, renal, or other medical conditions that may interfere with the interpretation of data or the patient's participation in the study or may increase safety concerns
History of cardiovascular diseases including uncontrolled hypertension (BP >160/100), ischemic heart disease, congestive heart failure (NYHA III or IV), valvular heart disease or cardiomyopathy
Known allergy or sensitivity to atropine or ipratropium bromide
Documented or self-reported current history of alcoholism or drug abuse
Participation in another research trial within 30 days of starting this trial
Unwillingness or inability to comply with study procedures
Inability to swallow the study medication
Pregnant or nursing
Current use of any OTC remedies containing pseudoephedrine, ephedrine-based or containing dietary or herbal supplements.
Scheduled for surgery requiring general anaesthesia
Referred for smoking cessation without serious commitment to quit