Predicting the Conversion From Mild Cognitive Impairment to Dementia (PCMCItoD)
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|ClinicalTrials.gov Identifier: NCT01823666|
Recruitment Status : Completed
First Posted : April 4, 2013
Last Update Posted : June 8, 2016
|Condition or disease|
|Mild Cognitive Impairment Alzheimer Disease Dementia, Vascular|
MCI increases the risk of later developing dementia. About 10-15% of the amnestic form of mild cognitive impairment will progress to Alzheimer's disease in one year. But some people with MCI never get worse. Others with MCI later have test results that return to normal for their age and education.
To develop a new drug for the prevention of dementia(dementia due to Alzheimer's disease or vascular dementia), investigators need a sensitive and specific tool for recognizing patients who will converse to dementia. The investigators want to establish an operational diagnostic criteria instead of a descriptive criteria for mild cognitive impairment.
|Study Type :||Observational|
|Actual Enrollment :||250 participants|
|Official Title:||Study on Risk Factors for Prediction of Conversion to Dementia in Patients With Mild Cognitive Impairment|
|Study Start Date :||September 2012|
|Actual Primary Completion Date :||August 2014|
|Actual Study Completion Date :||September 2014|
Mild cognitive impairment
People with cognitive complaint will be recruited. Who can be diagnosed as mild cognitive impairment will be enrolled according to the MCI criteria.
- Rate of conversion to dementia [ Time Frame: At baseline, 26 weeks, and 52 weeks. ]
- Mini-Mental State Examination [ Time Frame: At baseline, 26 weeks, and 52 weeks ]
- Immediate and delayed story recall [ Time Frame: At baseline, 26 weeks, and 52 weeks ]
- Clock Drawing Test(CDT) [ Time Frame: At baseline, 26 weeks, and 52 weeks ]
- Boston Naming Test [ Time Frame: At baseline, 26 weeks, and 52 weeks ]
- Verbal Category Fluency Test(animals) [ Time Frame: At baseline, 26 weeks, and 52 weeks ]
- Trail Making Test(TMT) [ Time Frame: At baseline, 26 weeks, and 52 weeks ]
- Hopkins Verbal Learning Test(HVLT) [ Time Frame: At baseline, 26 weeks, and 52 weeks ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01823666
|Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine|
|Beijing, Beijing, China, 100700|
|Principal Investigator:||Jinzhou Tian, Doctor||Dongzhimen Hospital, Beijing|