We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Metabolic and Cognitive Parameters Following Partial Sleep Deprivation

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2014 by Uppsala University.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01823263
First Posted: April 4, 2013
Last Update Posted: December 2, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Uppsala University
  Purpose
The purpose of this study is to determine whether partial sleep deprivation, as compared with normal sleep, influences certain metabolic and cognitive parameters, related to food intake, hunger and memory functions, when participants are shielded from external time cues.

Condition Intervention
Sleep Deprivation Sleep Behavioral: Portion Size Task Procedure: Blood sample Procedure: Interference task Behavioral: Memory tasks Behavioral: Intake task Behavioral: Working memory function task

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Metabolic and Cognitive Effects of Sleep Deprivation

Resource links provided by NLM:


Further study details as provided by Uppsala University:

Primary Outcome Measures:
  • Memory tasks [ Time Frame: Change in memory performance between learning (at 2230 hours in NS and PSD condition) before going to sleep, and at 0800 and 0930 hours (following PSD or NS) ]
    Procedural memory performance after learning a procedural memory task close to going to bed, followed by either partial sleep deprivation (PSD) or normal sleep (NS), and comparing the performance the following morning at two time points. Participants spatial memory performance in the morning at two time points, following PSD will also be compared with that following NS, after having learned such a memory task in the evening before going to bed.


Secondary Outcome Measures:
  • Circulating hormone levels [ Time Frame: Change in circulating hormone levels and other metabolism-linked and neurodegeneration-associated molecules at 0730, 0830, 0910, 0925, 0940, 1010, 1040, 1105, and 1150 hours following the respective nighttime intervention and after the interference task ]
    Interference task given at 0900 hours

  • Intake task [ Time Frame: Change in intake at around 1200 hours, following the respective nighttime intervention (NS or PSD) ]
    Participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded.

  • Working memory function task [ Time Frame: Change in memory performance at 0800 hours and after the interference task again at 0930 hours (between and following PSD or NS) ]
    Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD) and before and after an interference task

  • Portion Size Task [ Time Frame: Change in selected portion size from baseline (at 0800 hours following the nighttime intervention), to one hour later, i.e. after an interference task ]
    Participants will be evaluated on their tendency to choose larger or smaller portions of a variety of meal items on a computer screen. This will be conducted both following partial sleep deprivation and normal sleep, and changes before and after a short interference task will be compared between these two conditions.


Estimated Enrollment: 20
Study Start Date: April 2013
Estimated Study Completion Date: March 2015
Estimated Primary Completion Date: March 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Partial sleep deprivation
Partial sleep deprivation: participants will have a 4-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed by repeated blood sampling and an 'Intake task'.
Behavioral: Portion Size Task
Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
Procedure: Blood sample
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
Procedure: Interference task
30-minute interference task
Behavioral: Memory tasks
Participants will be allowed to learn a procedural memory task before going to bed. Participants will be retested in the morning to assess their change in performance. Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
Behavioral: Intake task
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded
Behavioral: Working memory function task
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)
Experimental: Normal sleep
Normal sleep: participants will have an 8-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed. This will be followed by an 'Interference task', followed with repeated blood sampling and an 'Intake task'.
Behavioral: Portion Size Task
Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume
Procedure: Blood sample
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
Procedure: Interference task
30-minute interference task
Behavioral: Memory tasks
Participants will be allowed to learn a procedural memory task before going to bed. Participants will be retested in the morning to assess their change in performance. Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
Behavioral: Intake task
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window. Amount and selection will be recorded
Behavioral: Working memory function task
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)

Detailed Description:
It is predicted that partial sleep deprivation negatively affects the hormonal status, e.g. upregulating ghrelin and other hunger-promoting hunger hormones, while showing impaired memory functions. It is also predicted that participants will tend to increase their desired portion sizes after partial sleep deprivation, compared with after a normal night's sleep.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years to 28 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male
  • Age 20-28y
  • Healthy (self-reported) and not on medication
  • Non-smoking
  • Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported and verified by sleep diaries)
  • Normal dietary habits (regular meal pattern with daily breakfast)

Exclusion Criteria:

  • Major illness
  • Taking any serious medications
  • Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
  • Any dietary issues with the food items provided
  • A history of endocrine, neurological or psychiatric disorders
  • Shift work in the previous 3 months
  • Travel over several time zones within the previous two months
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01823263


Contacts
Contact: Jonathan Cedernaes, M.D., PhD jonathan.cedernaes@neuro.uu.se
Contact: Christian Benedict, PhD christian.benedict@neuro.uu.se

Locations
Sweden
Department of Neuroscience, Uppsala University Recruiting
Uppsala, Sweden, 75105
Contact: Jonathan Cedernaes, M.D, PhD         
Contact: Christian Benedict, PhD         
Principal Investigator: Christian Benedict, PhD         
Sponsors and Collaborators
Uppsala University
Investigators
Principal Investigator: Christian Benedict, PhD Department of Neuroscience, Uppsala University
  More Information

Responsible Party: Uppsala University
ClinicalTrials.gov Identifier: NCT01823263     History of Changes
Other Study ID Numbers: SleepPartialJCCB2013
First Submitted: February 21, 2013
First Posted: April 4, 2013
Last Update Posted: December 2, 2014
Last Verified: November 2014

Additional relevant MeSH terms:
Sleep Deprivation
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders