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Physiological Response of Cortisol to Cardiac Catheterization

This study has been completed.
Information provided by (Responsible Party):
Creighton University Identifier:
First received: March 28, 2013
Last updated: February 24, 2015
Last verified: February 2015
Cortisol is essential for survival. The importance of cortisol response is most apparent in patients with partial or complete deficiency of glucocorticoids during stressful events such as illness or surgery.

Adrenal Insufficiency

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Cross-Sectional
Official Title: Physiological Response of Cortisol to Cardiac Catheterization

Resource links provided by NLM:

Further study details as provided by Creighton University:

Primary Outcome Measures:
  • cortisol change [ Time Frame: one month ]
    On the day of the procedure a total of 4 venous blood samples for random plasma cortisol level will be obtained. Blood will be drawn at 5 minutes prior to the procedure, at 30 minutes and 60 minutes during the cardiac catheterization. Another sample will be drawn in 3 hours after cardiac catheterization prior to the patients discharge. a cortisol level will be drawn at a "nonstressful" visit

Enrollment: 24
Study Start Date: March 2013
Study Completion Date: April 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
patients undergoing elective heart catheterization

Detailed Description:
It is known that cortisol and other stress hormones increase during acute myocardial infarction as well (9-11). Cardiac catheterization is an essential tool for the management of acute coronary syndrome, and for the evaluation of the burden of coronary artery disease in cardiac patients.

Ages Eligible for Study:   20 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
30 males and females, age 20-90 years who are scheduled for elective cardiac catheterization procedure.

Inclusion Criteria:

  • Patients undergoing elective cardiac catheterization, who are willing and able to give consent.

Exclusion Criteria:

  • • Patients with .primary or secondary adrenal insufficiency.

    • Patients taking steroids in the doses equivalent of at least 5 mg of prednisone daily for more than 3 weeks in the previous year.
    • Patients undergoing cardiac catheterization in the setting of acute coronary syndrome, eg. STEMI, NSTEMI and unstable angina.
    • Patients with low albumin level (<3.5 g/dL)
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Please refer to this study by its identifier: NCT01822847

United States, Nebraska
Creighton University
Omaha, Nebraska, United States, 68131
Sponsors and Collaborators
Creighton University
Principal Investigator: Valentina Tarasova, MD Creighton University
  More Information

Responsible Party: Creighton University Identifier: NCT01822847     History of Changes
Other Study ID Numbers: 12-16583
Study First Received: March 28, 2013
Last Updated: February 24, 2015

Keywords provided by Creighton University:

Additional relevant MeSH terms:
Adrenal Insufficiency
Adrenal Gland Diseases
Endocrine System Diseases
Hydrocortisone 17-butyrate 21-propionate
Cortisol succinate
Hydrocortisone acetate
Anti-Inflammatory Agents processed this record on April 21, 2017