Pistachios, Performance, Metabolomics
Ingestion of 3 ounces of pistachio nuts per day for two weeks before and the day of cycling intensely for 75 kilometers will support substrate utilization during exercise (as determined through metabolomics) and improve performance compared to water only, and attenuate inflammation, oxidative stress, and immune dysfunction during 24 hours of recovery.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:||Influence of Pistachios on Performance and Exercise-induced Inflammation, Oxidative Stress, and Immune Dysfunction in Athletes: a Metabolomics-based Approach.|
- Shifts in metabolites (metabolomics) [ Time Frame: 14-day period ] [ Designated as safety issue: No ]Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.
- Inflammation [ Time Frame: 14-day period ] [ Designated as safety issue: No ]Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein
- Immune Function [ Time Frame: 14-day period ] [ Designated as safety issue: No ]Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential
- Oxidative Stress [ Time Frame: 14-day period ] [ Designated as safety issue: No ]Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes
|Study Start Date:||March 2013|
|Study Completion Date:||July 2014|
|Primary Completion Date:||June 2014 (Final data collection date for primary outcome measure)|
Pistachio treatment (3 oz/d) for two weeks; 3 oz pistachio nuts and water (1.5 oz. before, and 1.5 oz during) cycling 75 km.
No Intervention: No pistachios
No pistachios for two weeks, or before and during 75 km cycling.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01821820
|United States, North Carolina|
|ASU Human Performance Laboratory, North Carolina Research Campus|
|Kannapolis, North Carolina, United States, 28787|
|Principal Investigator:||David C. Nieman, DrPH||Appalachian State University|