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Pistachios, Performance, Metabolomics

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: April 1, 2013
Last Update Posted: February 2, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
American Pistachio Growers
Information provided by (Responsible Party):
Appalachian State University
Ingestion of 3 ounces of pistachio nuts per day for two weeks before and the day of cycling intensely for 75 kilometers will support substrate utilization during exercise (as determined through metabolomics) and improve performance compared to water only, and attenuate inflammation, oxidative stress, and immune dysfunction during 24 hours of recovery.

Condition Intervention
Inflammation Oxidative Stress Immune Dysfunction Other: Pistachios

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Influence of Pistachios on Performance and Exercise-induced Inflammation, Oxidative Stress, and Immune Dysfunction in Athletes: a Metabolomics-based Approach.

Further study details as provided by Appalachian State University:

Primary Outcome Measures:
  • Shifts in metabolites (metabolomics) [ Time Frame: 14-day period ]
    Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.

Secondary Outcome Measures:
  • Inflammation [ Time Frame: 14-day period ]
    Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein

  • Immune Function [ Time Frame: 14-day period ]
    Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential

  • Oxidative Stress [ Time Frame: 14-day period ]
    Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes

Enrollment: 40
Study Start Date: March 2013
Study Completion Date: July 2014
Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Pistachios
Pistachio treatment (3 oz/d) for two weeks; 3 oz pistachio nuts and water (1.5 oz. before, and 1.5 oz during) cycling 75 km.
Other: Pistachios
No Intervention: No pistachios
No pistachios for two weeks, or before and during 75 km cycling.


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male endurance cyclists
  • Capable of exercising for 2.5 h at a high intensity in the lab
  • Ages 18-55
  • Agree to train normally and stay weight stable.
  • Agree to avoid the use of large dose vitamin/mineral supplements
  • Agree to avoid herbs and medications that influence inflammation

Exclusion Criteria:

  • Regularly take supplements or medicines known to effect inflammation.
  • At moderate or high risk for cardiovascular disease.
  • Younger than 18 or older than 55 years of age.
  • No history of competing in cycling races.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01821820

United States, North Carolina
ASU Human Performance Laboratory, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28787
Sponsors and Collaborators
Appalachian State University
American Pistachio Growers
Principal Investigator: David C. Nieman, DrPH Appalachian State University
  More Information

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Appalachian State University
ClinicalTrials.gov Identifier: NCT01821820     History of Changes
Other Study ID Numbers: 13-0064
First Submitted: March 27, 2013
First Posted: April 1, 2013
Last Update Posted: February 2, 2015
Last Verified: January 2015

Keywords provided by Appalachian State University:
Oxidative stress
Immune dysfunction

Additional relevant MeSH terms:
Immune System Diseases
Pathologic Processes