Pistachios, Performance, Metabolomics
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01821820|
Recruitment Status : Completed
First Posted : April 1, 2013
Last Update Posted : February 2, 2015
|Condition or disease||Intervention/treatment||Phase|
|Inflammation Oxidative Stress Immune Dysfunction||Other: Pistachios||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Influence of Pistachios on Performance and Exercise-induced Inflammation, Oxidative Stress, and Immune Dysfunction in Athletes: a Metabolomics-based Approach.|
|Study Start Date :||March 2013|
|Actual Primary Completion Date :||June 2014|
|Actual Study Completion Date :||July 2014|
Pistachio treatment (3 oz/d) for two weeks; 3 oz pistachio nuts and water (1.5 oz. before, and 1.5 oz during) cycling 75 km.
No Intervention: No pistachios
No pistachios for two weeks, or before and during 75 km cycling.
- Shifts in metabolites (metabolomics) [ Time Frame: 14-day period ]Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.
- Inflammation [ Time Frame: 14-day period ]Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein
- Immune Function [ Time Frame: 14-day period ]Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential
- Oxidative Stress [ Time Frame: 14-day period ]Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01821820
|United States, North Carolina|
|ASU Human Performance Laboratory, North Carolina Research Campus|
|Kannapolis, North Carolina, United States, 28787|
|Principal Investigator:||David C. Nieman, DrPH||Appalachian State University|