Manipulation of Dietary Protein and the Anabolic Response (PRO-ADAPT)

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Maastricht University Medical Center

ClinicalTrials.gov Identifier:

NCT01820975

First received: March 18, 2013

Last updated: March 15, 2016

Last verified: May 2015

History of Changes

Purpose

In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.

Condition	Intervention
Focus: Anabolic Response to Food Intake in Young Individuals. Condition Relevance: Skeletal Muscle Health, Sarcopenia.	Dietary Supplement: High protein intake Other: Placebo comparator


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single Blind (Subject) Primary Purpose: Basic Science
Official Title:	The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men

Resource links provided by NLM:

MedlinePlus related topics: Dietary Proteins

U.S. FDA Resources

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:

Muscle protein fractional synthetic rate following protein ingestion [ Time Frame: 3 hours ] [ Designated as safety issue: No ]
The ability of the muscle to synthesise new proteins will be assessed over a 3 h period following protein ingestion and will be compared between groups. This only occurs on one occasion.


Enrollment:	28
Study Start Date:	April 2013
Primary Completion Date:	March 2015 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: High protein intake High protein intake: large bolus of protein in teh diet the day before testing	Dietary Supplement: High protein intake
Placebo Comparator: No protein intake No protein in the diet the day before testing	Other: Placebo comparator No protein intake Other Name: control group

Eligibility


Ages Eligible for Study:	18 Years to 35 Years (Adult)
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Males
Aged between 18-35 years
Healthy, recreationally active
BMI < 30 kg/m2

Exclusion Criteria:

Smoking
Allergies to milk proteins (whey or casein)
Vegetarians
Diagnosed GI tract diseases
Female
Arthritic conditions
A history of neuromuscular problems
Previous participation in amino acid tracer studies
Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01820975

Sponsors and Collaborators

Maastricht University Medical Center

Investigators


Principal Investigator:	Luc JC van Loon, PhD	Maastricht University

More Information


Responsible Party:	Maastricht University Medical Center
ClinicalTrials.gov Identifier:	NCT01820975 History of Changes
Other Study ID Numbers:	METC 12-3-067
Study First Received:	March 18, 2013
Last Updated:	March 15, 2016
Health Authority:	Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Maastricht University Medical Center:


Muscle protein synthesis Dietary protein

Additional relevant MeSH terms:


Sarcopenia Muscular Atrophy Neuromuscular Manifestations Neurologic Manifestations	Nervous System Diseases Atrophy Pathological Conditions, Anatomical Signs and Symptoms

ClinicalTrials.gov processed this record on September 30, 2016

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