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Manipulation of Dietary Protein and the Anabolic Response (PRO-ADAPT)

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ClinicalTrials.gov Identifier: NCT01820975
Recruitment Status : Completed
First Posted : March 29, 2013
Last Update Posted : March 22, 2017
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center

Study Description
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Brief Summary:
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.

Condition or disease Intervention/treatment Phase
Focus: Anabolic Response to Food Intake in Young Individuals Condition Relevance: Skeletal Muscle Health, Sarcopenia Dietary Supplement: High protein intake Other: Placebo comparator Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 28 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men
Study Start Date : April 2013
Actual Primary Completion Date : March 2015
Actual Study Completion Date : February 1, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dietary Proteins
U.S. FDA Resources

Arms and Interventions
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Arm Intervention/treatment
Experimental: High protein intake
High protein intake: large bolus of protein in teh diet the day before testing
 Dietary Supplement: High protein intake
Placebo Comparator: No protein intake
No protein in the diet the day before testing
 Other: Placebo comparator
No protein intake
Other Name: control group


Outcome Measures
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Primary Outcome Measures :
  1. Muscle protein fractional synthetic rate following protein ingestion [ Time Frame: 3 hours ]
    The ability of the muscle to synthesise new proteins will be assessed over a 3 h period following protein ingestion and will be compared between groups. This only occurs on one occasion.


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Males
  • Aged between 18-35 years
  • Healthy, recreationally active
  • BMI < 30 kg/m2

Exclusion Criteria:

  • Smoking
  • Allergies to milk proteins (whey or casein)
  • Vegetarians
  • Diagnosed GI tract diseases
  • Female
  • Arthritic conditions
  • A history of neuromuscular problems
  • Previous participation in amino acid tracer studies
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications
Contacts and Locations
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01820975


Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Luc JC van Loon, PhD Maastricht University
More Information
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01820975     History of Changes
Other Study ID Numbers: METC 12-3-067
First Posted: March 29, 2013    Key Record Dates
Last Update Posted: March 22, 2017
Last Verified: May 2015

Keywords provided by Maastricht University Medical Center:
Muscle protein synthesis
Dietary protein

Additional relevant MeSH terms:
Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
 Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms