Manipulation of Dietary Protein and the Anabolic Response (PRO-ADAPT)
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ClinicalTrials.gov Identifier: NCT01820975 |
Recruitment Status
:
Completed
First Posted
: March 29, 2013
Last Update Posted
: March 22, 2017
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Focus: Anabolic Response to Food Intake in Young Individuals Condition Relevance: Skeletal Muscle Health, Sarcopenia | Dietary Supplement: High protein intake Other: Placebo comparator | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 28 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Participant) |
Primary Purpose: | Basic Science |
Official Title: | The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men |
Study Start Date : | April 2013 |
Actual Primary Completion Date : | March 2015 |
Actual Study Completion Date : | February 1, 2017 |

Arm | Intervention/treatment |
---|---|
Experimental: High protein intake
High protein intake: large bolus of protein in teh diet the day before testing
|
Dietary Supplement: High protein intake |
Placebo Comparator: No protein intake
No protein in the diet the day before testing
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Other: Placebo comparator
No protein intake
Other Name: control group
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- Muscle protein fractional synthetic rate following protein ingestion [ Time Frame: 3 hours ]The ability of the muscle to synthesise new proteins will be assessed over a 3 h period following protein ingestion and will be compared between groups. This only occurs on one occasion.

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Ages Eligible for Study: | 18 Years to 35 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Males
- Aged between 18-35 years
- Healthy, recreationally active
- BMI < 30 kg/m2
Exclusion Criteria:
- Smoking
- Allergies to milk proteins (whey or casein)
- Vegetarians
- Diagnosed GI tract diseases
- Female
- Arthritic conditions
- A history of neuromuscular problems
- Previous participation in amino acid tracer studies
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01820975
Principal Investigator: | Luc JC van Loon, PhD | Maastricht University |
Responsible Party: | Maastricht University Medical Center |
ClinicalTrials.gov Identifier: | NCT01820975 History of Changes |
Other Study ID Numbers: |
METC 12-3-067 |
First Posted: | March 29, 2013 Key Record Dates |
Last Update Posted: | March 22, 2017 |
Last Verified: | May 2015 |
Keywords provided by Maastricht University Medical Center:
Muscle protein synthesis Dietary protein |
Additional relevant MeSH terms:
Sarcopenia Muscular Atrophy Neuromuscular Manifestations Neurologic Manifestations |
Nervous System Diseases Atrophy Pathological Conditions, Anatomical Signs and Symptoms |