Manipulation of Dietary Protein and the Anabolic Response (PRO-ADAPT)

This study has been completed.

Sponsor:

ClinicalTrials.gov Identifier:

NCT01820975

First Posted: March 29, 2013

Last Update Posted: March 22, 2017

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Information provided by (Responsible Party):

Maastricht University Medical Center

Purpose

In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.

Condition	Intervention
Focus: Anabolic Response to Food Intake in Young Individuals Condition Relevance: Skeletal Muscle Health, Sarcopenia	Dietary Supplement: High protein intake Other: Placebo comparator


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Basic Science
Official Title:	The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men

Resource links provided by NLM:

MedlinePlus related topics: Dietary Proteins

U.S. FDA Resources

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:

Muscle protein fractional synthetic rate following protein ingestion [ Time Frame: 3 hours ]
The ability of the muscle to synthesise new proteins will be assessed over a 3 h period following protein ingestion and will be compared between groups. This only occurs on one occasion.


Enrollment:	28
Study Start Date:	April 2013
Study Completion Date:	February 1, 2017
Primary Completion Date:	March 2015 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: High protein intake High protein intake: large bolus of protein in teh diet the day before testing	Dietary Supplement: High protein intake
Placebo Comparator: No protein intake No protein in the diet the day before testing	Other: Placebo comparator No protein intake Other Name: control group

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:	18 Years to 35 Years (Adult)
Sexes Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Males
Aged between 18-35 years
Healthy, recreationally active
BMI < 30 kg/m2

Exclusion Criteria:

Smoking
Allergies to milk proteins (whey or casein)
Vegetarians
Diagnosed GI tract diseases
Female
Arthritic conditions
A history of neuromuscular problems
Previous participation in amino acid tracer studies
Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01820975

Sponsors and Collaborators

Maastricht University Medical Center

Investigators


Principal Investigator:	Luc JC van Loon, PhD	Maastricht University

More Information


Responsible Party:	Maastricht University Medical Center
ClinicalTrials.gov Identifier:	NCT01820975 History of Changes
Other Study ID Numbers:	METC 12-3-067
First Submitted:	March 18, 2013
First Posted:	March 29, 2013
Last Update Posted:	March 22, 2017
Last Verified:	May 2015

Keywords provided by Maastricht University Medical Center:


Muscle protein synthesis Dietary protein

Additional relevant MeSH terms:


Sarcopenia Muscular Atrophy Neuromuscular Manifestations Neurologic Manifestations	Nervous System Diseases Atrophy Pathological Conditions, Anatomical Signs and Symptoms

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