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Manipulation of Dietary Protein and the Anabolic Response (PRO-ADAPT)

This study has been completed.
Information provided by (Responsible Party):
Maastricht University Medical Center Identifier:
First received: March 18, 2013
Last updated: March 21, 2017
Last verified: May 2015
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.

Condition Intervention
Focus: Anabolic Response to Food Intake in Young Individuals Condition Relevance: Skeletal Muscle Health, Sarcopenia Dietary Supplement: High protein intake Other: Placebo comparator

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men

Resource links provided by NLM:

Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Muscle protein fractional synthetic rate following protein ingestion [ Time Frame: 3 hours ]
    The ability of the muscle to synthesise new proteins will be assessed over a 3 h period following protein ingestion and will be compared between groups. This only occurs on one occasion.

Enrollment: 28
Study Start Date: April 2013
Study Completion Date: February 1, 2017
Primary Completion Date: March 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: High protein intake
High protein intake: large bolus of protein in teh diet the day before testing
Dietary Supplement: High protein intake
Placebo Comparator: No protein intake
No protein in the diet the day before testing
Other: Placebo comparator
No protein intake
Other Name: control group


Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Males
  • Aged between 18-35 years
  • Healthy, recreationally active
  • BMI < 30 kg/m2

Exclusion Criteria:

  • Smoking
  • Allergies to milk proteins (whey or casein)
  • Vegetarians
  • Diagnosed GI tract diseases
  • Female
  • Arthritic conditions
  • A history of neuromuscular problems
  • Previous participation in amino acid tracer studies
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications
  Contacts and Locations
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Please refer to this study by its identifier: NCT01820975

Sponsors and Collaborators
Maastricht University Medical Center
Principal Investigator: Luc JC van Loon, PhD Maastricht University
  More Information

Responsible Party: Maastricht University Medical Center Identifier: NCT01820975     History of Changes
Other Study ID Numbers: METC 12-3-067
Study First Received: March 18, 2013
Last Updated: March 21, 2017

Keywords provided by Maastricht University Medical Center:
Muscle protein synthesis
Dietary protein

Additional relevant MeSH terms:
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Pathological Conditions, Anatomical
Signs and Symptoms processed this record on August 23, 2017