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Creatine Supplementation on Kidney Function in Resistance-trained Individuals

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ClinicalTrials.gov Identifier: NCT01817673
Recruitment Status : Completed
First Posted : March 25, 2013
Last Update Posted : March 25, 2013
Sponsor:
Information provided by (Responsible Party):
Bruno Gualano, University of Sao Paulo

Brief Summary:
There is a claim that creatine supplementation might affect kidney function, especially in those consuming a high-protein diet. The aim of this study was to investigate the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet.

Condition or disease Intervention/treatment Phase
Healthy Persons Dietary Supplement: creatine Dietary Supplement: placebo Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 46 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Study Start Date : July 2011
Actual Primary Completion Date : February 2013
Actual Study Completion Date : February 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: creatine
20 g/d for 5 d followed by 5 g/d throughout the trial
Dietary Supplement: creatine
20 g/d for 5 d followed by 5 g/d throughout the trial

Placebo Comparator: placebo (dextrose)
20 g/d for 5 d followed by 5 g/d throughout the trial
Dietary Supplement: placebo



Primary Outcome Measures :
  1. kidney function [ Time Frame: 3 months ]
    as assessed by 51Cr-EDTA clearance


Secondary Outcome Measures :
  1. proteinuria [ Time Frame: 3 months ]
  2. albuminuria [ Time Frame: 3 months ]
  3. serum urea [ Time Frame: 3 months ]
  4. serum creatinine [ Time Frame: 3 months ]


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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • participation in recreational resistance training
  • consumption of a high-protein diet (≥ 1.2 g/Kg/d)

Exclusion Criteria:

  • vegetarian diet
  • use of creatine supplements in the past 6 months
  • chronic kidney disease
  • use of anabolic steroids.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01817673


Locations
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Brazil
Univsersity of Sao Paulo
Sao Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
Investigators
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Principal Investigator: Bruno Gualano, Professor University of Sao Paulo

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Bruno Gualano, Professor, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT01817673     History of Changes
Other Study ID Numbers: Creatine & kidney
First Posted: March 25, 2013    Key Record Dates
Last Update Posted: March 25, 2013
Last Verified: March 2013