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Neuromodulation to Facilitate the Effect of Ketamine (TMS/ketamine)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01816958
First Posted: March 22, 2013
Last Update Posted: March 22, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
The Neuroscience Center, LLC
  Purpose
application of external neuromodulation along with ketamine infusion.

Condition Intervention
Depression Chronic Pain Substance Abuse Other: co-administration of TMS and infused ketamine

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Treatment of Thalamocortical Dysrhythmia Using External Neuromodulation to Facilitate the Therapeutic Effect of Ketamine.

Resource links provided by NLM:


Further study details as provided by The Neuroscience Center, LLC:

Primary Outcome Measures:
  • Global Assessment of Function in DSM-4R [ Time Frame: up to 3 years ]
    treat in order to cause remission of disability


Enrollment: 35
Study Start Date: January 2011
Study Completion Date: November 2012
Primary Completion Date: November 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
chronic depression and/or pain
co-administration of TMS and infused ketamine for patients with chronic pain of psyche and/or soma
Other: co-administration of TMS and infused ketamine
co-administration of TMS and infused ketamine

Detailed Description:
apply TMS concurrent with ketamine infusion in order to increase the likliehood & strength of therapeutic benefit
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients within my own clinic, suffering with chronic emotional and/or somatic pain
Criteria

Inclusion Criteria:

  • chronically ill,
  • treatment-resistant

Exclusion Criteria:

  • active psychosis
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01816958


Locations
United States, Illinois
The Neuroscience Center
Deerfield, Illinois, United States, 60015
Sponsors and Collaborators
The Neuroscience Center, LLC
Investigators
Principal Investigator: Steven R Devore Best, M.D. The Neuroscience Center
  More Information

Responsible Party: The Neuroscience Center, LLC
ClinicalTrials.gov Identifier: NCT01816958     History of Changes
Other Study ID Numbers: 12_1293
First Submitted: March 11, 2013
First Posted: March 22, 2013
Last Update Posted: March 22, 2013
Last Verified: March 2013

Keywords provided by The Neuroscience Center, LLC:
thalamocortical dysrhythmia
transcranial magnetic stimulation (TMS)
transcranial Electrical Stimulation (tES)
(N-methyl-D-aspartate) NMDA-R antagonist
ketamine infusion
neuromodulation
synergistic effect
remission

Additional relevant MeSH terms:
Chronic Pain
Substance-Related Disorders
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Chemically-Induced Disorders
Mental Disorders
Ketamine
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action