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Neuromodulation to Facilitate the Effect of Ketamine (TMS/ketamine)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01816958
Recruitment Status : Completed
First Posted : March 22, 2013
Last Update Posted : March 22, 2013
Information provided by (Responsible Party):
The Neuroscience Center, LLC

Brief Summary:
application of external neuromodulation along with ketamine infusion.

Condition or disease Intervention/treatment
Depression Chronic Pain Substance Abuse Other: co-administration of TMS and infused ketamine

Detailed Description:
apply TMS concurrent with ketamine infusion in order to increase the likliehood & strength of therapeutic benefit

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Study Type : Observational
Actual Enrollment : 35 participants
Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Treatment of Thalamocortical Dysrhythmia Using External Neuromodulation to Facilitate the Therapeutic Effect of Ketamine.
Study Start Date : January 2011
Actual Primary Completion Date : November 2012
Actual Study Completion Date : November 2012

Resource links provided by the National Library of Medicine

Drug Information available for: Ketamine

Group/Cohort Intervention/treatment
chronic depression and/or pain
co-administration of TMS and infused ketamine for patients with chronic pain of psyche and/or soma
Other: co-administration of TMS and infused ketamine
co-administration of TMS and infused ketamine

Primary Outcome Measures :
  1. Global Assessment of Function in DSM-4R [ Time Frame: up to 3 years ]
    treat in order to cause remission of disability

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients within my own clinic, suffering with chronic emotional and/or somatic pain

Inclusion Criteria:

  • chronically ill,
  • treatment-resistant

Exclusion Criteria:

  • active psychosis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01816958

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United States, Illinois
The Neuroscience Center
Deerfield, Illinois, United States, 60015
Sponsors and Collaborators
The Neuroscience Center, LLC
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Principal Investigator: Steven R Devore Best, M.D. The Neuroscience Center

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Responsible Party: The Neuroscience Center, LLC Identifier: NCT01816958     History of Changes
Other Study ID Numbers: 12_1293
First Posted: March 22, 2013    Key Record Dates
Last Update Posted: March 22, 2013
Last Verified: March 2013
Keywords provided by The Neuroscience Center, LLC:
thalamocortical dysrhythmia
transcranial magnetic stimulation (TMS)
transcranial Electrical Stimulation (tES)
(N-methyl-D-aspartate) NMDA-R antagonist
ketamine infusion
synergistic effect
Additional relevant MeSH terms:
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Chronic Pain
Substance-Related Disorders
Neurologic Manifestations
Signs and Symptoms
Chemically-Induced Disorders
Mental Disorders
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Central Nervous System Depressants
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action