Does Pulmonary Rehabilitation Improve Breathing of COPD Patients (PR-COPD)
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death world-wide. Dyspnea (i.e., sensations of breathlessness) is the hallmark symptom of patients with this disease. Pulmonary rehabilitation programs that incorporate exercise training remain the most effective non-pharmacological method of reducing dyspnea in COPD, however it is not understood how exercise training relieves dyspnea. Accordingly, the purpose of this study is to determine if pulmonary rehabilitation can reduce the disparity between the drive to breathe and the breathing response in patients with COPD and to determine if this reduction is associated with improvements in dyspnea during exercise.
The investigators hypothesise pulmonary rehabilitation will reduce dyspnea at a standardized work rate and this reduction will be directly related to an improvement in the breathing response.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Supportive Care
|Official Title:||Does Pulmonary Rehabilitation Reduce Neuromechanical Uncoupling of the Respiratory System in COPD|
- Change in neuromechanical uncoupling [ Time Frame: Parameters will be measured during the 3 visits, at rest and during exercise. Visits 1 & 2 will be 48 hrs apart and within 2 weeks prior to the 8 week pulmonary rehabilitation (PR). Visit 3 will occur within 2 weeks after the completion of the PR. ]The relationship between the neural drive (or effort) to breathe and the corresponding mechanical response of the respiratory system.
- Dyspnea [ Time Frame: Parameters will be measured during the 3 visits, at rest and during exercise. Visits 1 & 2 will be 48 hrs apart and within 2 weeks prior to the 8 week pulmonary rehabilitation (PR). Visit 3 will occur within 2 weeks after the completion of the PR. ]Intensity (BORG scale) and qualitative dimensions (dyspnea descriptors) of dyspnea.
|Study Start Date:||January 2017|
|Estimated Study Completion Date:||December 2018|
|Estimated Primary Completion Date:||December 2018 (Final data collection date for primary outcome measure)|
Experimental: Pulmonary Rehabilitation
8 weeks of Pulmonary Rehabilitation
Behavioral: Pulmonary Rehabilitation
8 weeks of Pulmonary Rehabilitation including exercise and COPD related education.
Show Detailed Description
Please refer to this study by its ClinicalTrials.gov identifier: NCT01815970
|Contact: Sabrina S Wilkie, M.Sc.||firstname.lastname@example.org|
|Contact: Jordan A Guenette, Ph.D.||604.682.2344 ext email@example.com|
|Canada, British Columbia|
|UBC James Hogg Research Centre, St. Paul's Hospital||Recruiting|
|Vancouver, British Columbia, Canada, V6Z1Y6|
|Principal Investigator: Jordan A Guenette, Ph.D.|
|Sub-Investigator: Pat Camp, Ph.D.|
|Sub-Investigator: Chris Ryerson, M.D.|
|Principal Investigator:||Jordan A Guenette, Ph.D.||UBC James Hogg Research Centre/ UBC Dept. Physical Therapy|