Role of Neutrophil Activation
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|ClinicalTrials.gov Identifier: NCT01815229|
Recruitment Status : Recruiting
First Posted : March 20, 2013
Last Update Posted : April 5, 2017
Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal lavage will be conducted using 5 mL of sterile saline solution by a push/suction technique. Specimen samples obtained by wall suction will be collected at 2 time points following intubation.
Blood samples will be obtained at 2 time points, simultaneous with the collection of the tracheal specimens.
|Condition or disease||Intervention/treatment|
|Patients Requiring Endotracheal Intubation||Procedure: tracheal lavages|
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Official Title:||Sore Throat Secondary to Endotracheal Intubation: the Role of Neutrophil Activation|
|Study Start Date :||March 2013|
|Estimated Primary Completion Date :||December 2017|
|Estimated Study Completion Date :||April 2018|
After the placement of the endotracheal tube (Hi-Lo™ Evac Mallinckrodt), tracheal lavages will be performed.
A simultaneous blood sample of approx 5cc, will be collected by venipuncture or by sampling from intravenous or arterial line if available. The same procedure for collection of tracheal sample and blood will be repeated at the end of the surgical procedure and immediately prior to removal of the ETT. A total of approx 10cc blood will be collected for research purposes.
Procedure: tracheal lavages
tracheal lavages obtained during endotracheal intubation.
- identifying neutrophil surface changes [ Time Frame: 90 minutes after surgery ]Physiologic and demographic measurements such as temperature, oxygenation, and blood pressure, gender, body mass index and coexisting diseases
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01815229
|United States, Missouri|
|Washington University School of Medicine||Recruiting|
|St. Louis, Missouri, United States, 63110|
|Contact: Carlos A Puyo, MD, FCCP 314-747-0259 email@example.com|
|Principal Investigator: Carlos A Puyo, MD, FCCP|
|Principal Investigator:||Carlos Puyo, MD||Washington University School of Medicine|