Role of Neutrophil Activation
Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal lavage will be conducted using 5 mL of sterile saline solution by a push/suction technique. Specimen samples obtained by wall suction will be collected at 2 time points following intubation.
Blood samples will be obtained at 2 time points, simultaneous with the collection of the tracheal specimens.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Sore Throat Secondary to Endotracheal Intubation: the Role of Neutrophil Activation|
- identifying neutrophil surface changes [ Time Frame: 90 minutes after surgery ] [ Designated as safety issue: No ]Physiologic and demographic measurements such as temperature, oxygenation, and blood pressure, gender, body mass index and coexisting diseases
|Study Start Date:||March 2013|
|Estimated Study Completion Date:||April 2017|
|Estimated Primary Completion Date:||December 2016 (Final data collection date for primary outcome measure)|
After the placement of the endotracheal tube (Hi-Lo™ Evac Mallinckrodt), tracheal lavages will be performed.
A simultaneous blood sample of approx 5cc, will be collected by venipuncture or by sampling from intravenous or arterial line if available. The same procedure for collection of tracheal sample and blood will be repeated at the end of the surgical procedure and immediately prior to removal of the ETT. A total of approx 10cc blood will be collected for research purposes.
Procedure: tracheal lavages
tracheal lavages obtained during endotracheal intubation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01815229
|United States, Missouri|
|Washington University School of Medicine||Recruiting|
|St. Louis, Missouri, United States, 63110|
|Contact: Carlos A Puyo, MD, FCCP 314-747-0259 firstname.lastname@example.org|
|Principal Investigator: Carlos A Puyo, MD, FCCP|
|Principal Investigator:||Carlos Puyo, MD||Washington University School of Medicine|