IgA-positive Versus IgA-negative Immune Complex Vasculitis
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|ClinicalTrials.gov Identifier: NCT01815190|
Recruitment Status : Unknown
Verified November 2015 by Cord Sunderkötter, University Hospital Muenster.
Recruitment status was: Recruiting
First Posted : March 20, 2013
Last Update Posted : December 2, 2015
Cutaneous vasculitis due to vascular deposition of large circulating immune complexes is a disease frequently seen by general practitioners and dermatologists. The clinical symptom is palpable purpura with predilection for the lower legs.
In some cases vasculitis also affects systemic organs, such as the kidneys and the intestine.
When the immune complexes contain immunoglobulin class A (IgA) and when there is systemic involvement, the disease has been referred to as Henoch Schönlein purpura.
When there are no signs of systemic involvement, the disease has been referred to as cutaneous leukocytoclastic angiitis.
The investigators hypothesize that palpable purpura with predilection for lower legs is a pathognomonic clinical sign for immune complex vasculitis in both IgA vasculitis and IgA-negative vasculitis, but that only the presence of IgA in immune complexes is likely to be associated with systemic involvement and therefore warrants more extensive diagnostic procedures Vice versa the investigators postulate that the presence of IgG or IgM without IgA in immune complexes excludes systemic involvement The investigators also want to investigate to which of the 2 groups patients with palpable purpura and negative immunofluorescence should be assigned.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Retrospective Analysis of Frequency of Systemic Involvement in IgA-positive Cutaneous Immune Complex Vasculitis Versus IgA-negative Cutaneous Immune Complex Vasculitis|
|Study Start Date :||January 2011|
|Estimated Primary Completion Date :||December 2016|
|Estimated Study Completion Date :||December 2016|
Patients with immune complex vasculitis who show perivascular deposits of IgA
Patients with immune complex vasculitis who show no perivascular deposits of IgA
- Frequency of systemic involvement in patients with IgA-positive versus patients with non-IgA-positive immune complex vasculitis [ Time Frame: 10 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01815190
|Contact: Cord Sunderkötter, Prof Dr MD||+49 251 firstname.lastname@example.org|
|Contact: Ilka Herrgott, MD||+49 251 8356502|
|Department of Dermatology, Univ hospital of Muenster||Recruiting|
|Muenster, Germany, 48149|
|Contact: Cord Sunderkoetter, Prof Dr MD +492518357481 email@example.com|
|Principal Investigator:||Cord Sunderkoetter, Prof Dr MD||Department of Dermatology, Univ Hospital of Muenster|