Forced Oscillation Versus Spirometry in Diagnosing Post Pulmonary Transplant Bronchiolitis Obliterans Syndrome (OSCILLOPOUMON)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01807975
Recruitment Status : Completed
First Posted : March 8, 2013
Last Update Posted : July 28, 2016
Information provided by (Responsible Party):
Hopital Foch

Brief Summary:
A study to evaluate the role of forced oscillation in precocious diagnosis of bronchiolitis obliterans syndrome in patients with pulmonary transplant (time difference in detecting distal airways functional impairment by forced oscillation and the standard technique using spirometry).

Condition or disease Intervention/treatment Phase
Bronchiolitis Obliterans Syndrome Other: Forced oscillation Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 110 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Study Start Date : September 2011
Actual Primary Completion Date : September 2015
Actual Study Completion Date : September 2015

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: post allogreffe patients
Functional evaluation of distal airway by forced oscillation technique : relevance earlier diagnostic of pulmonary syndrom of oblitérant bronchiolit in post allogreffe patients
Other: Forced oscillation

Primary Outcome Measures :
  1. Time difference in diagnosing distal airways functional disturbance by forced oscillation and by spirometry (standard methode). [ Time Frame: 2 years ]

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients of more than 18 year-old.
  • Patients with cardiopulmonary transplant or bilateral lung transplant.
  • Clinically stable patients

Exclusion Criteria:

  • Patients already diagnosed with bronchiolitis obliterans.
  • Respiratory infection.
  • Acute graft rejection.
  • Mechanical complications (bronchial dehiscence, pneumothorax, pleural effusion).
  • Iatrogenic pneumopathy.
  • Inability to perform Respiratory function test.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01807975

Hôpital FOCH
Suresnes, Ile de France, France, 92150
Sponsors and Collaborators
Hopital Foch

Responsible Party: Hopital Foch Identifier: NCT01807975     History of Changes
Other Study ID Numbers: 2010/56
First Posted: March 8, 2013    Key Record Dates
Last Update Posted: July 28, 2016
Last Verified: May 2016

Additional relevant MeSH terms:
Bronchiolitis Obliterans
Pathologic Processes
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Infections