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The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

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ClinicalTrials.gov Identifier: NCT01807832
Recruitment Status : Unknown
Verified March 2013 by Tel-Aviv Sourasky Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : March 8, 2013
Last Update Posted : March 8, 2013
Sponsor:
Information provided by (Responsible Party):
Tel-Aviv Sourasky Medical Center

Brief Summary:
The purpose of this study is to determine whether the capsaicin challenge can improve the diagnosis, treatment, monitoring and follow-up in patients with chronic cough.

Condition or disease Intervention/treatment Phase
Chronic Cough Other: capsaicin challenge Not Applicable

Detailed Description:
Capsaicin is administrated in incremental concentrations with two inhalations of normal saline solution. Patients are instructed to exhale to functional residual capacity and than to inhale through the mouthpiece for 1 second (single breath inhalation). The number of coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of which the patient responded by 2 coughs, C5;the concentration of which the patient responded by 5 coughs. The challenge ends at C5.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 25 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.
Study Start Date : March 2013
Estimated Primary Completion Date : December 2013
Estimated Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Cough
Drug Information available for: Capsaicin

Arm Intervention/treatment
chronic cough
Capsaicine challenge in chronic cough patients
Other: capsaicin challenge



Primary Outcome Measures :
  1. cough reflex hypersensitivity [ Time Frame: 3 months ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with persisting cough for more than 3 months, without known respiratory or lung diseases

Exclusion Criteria:

  • Diagnosis of respiratory or lung diseases of any kind

Responsible Party: Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov Identifier: NCT01807832     History of Changes
Other Study ID Numbers: TASMC-13-LF-0695-CTIL
First Posted: March 8, 2013    Key Record Dates
Last Update Posted: March 8, 2013
Last Verified: March 2013

Keywords provided by Tel-Aviv Sourasky Medical Center:
chronic cough
cough reflex hypersensitivity
capsaicin

Additional relevant MeSH terms:
Cough
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Capsaicin
Antipruritics
Dermatologic Agents
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs