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Myocardial Blood Flow by 15O Water PET

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2013 by University of Edinburgh.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
University of Edinburgh Identifier:
First received: February 4, 2013
Last updated: March 4, 2013
Last verified: March 2013
Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Condition Intervention
Coronary Heart Disease Other: Computed tomography myocardial perfusion imaging Other: Oxygen 15 labelled water positron emission tomography

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Validation of Computed Tomography Myocardial Perfusion Imaging Using Quantification of Myocardial Blood Flow by Positron Emission Tomography With 15O-water

Resource links provided by NLM:

Further study details as provided by University of Edinburgh:

Primary Outcome Measures:
  • Myocardial blood flow [ Time Frame: 1 month ]
    Myocardial blood flow ( ml/g/min) measured by oxygen-15 water positron emission tomography

Secondary Outcome Measures:
  • Fractional flow reserve [ Time Frame: 1 month ]
    Fractional flow reserve measured during invasive coronary angiography

  • Myocardial perfusion [ Time Frame: 1 month ]
    Myocardial perfusion measured as hypoperfusion on adenosine computed tomography myocardial perfusion imaging

Estimated Enrollment: 30
Study Start Date: December 2012
Estimated Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Suspected coronary heart disease Other: Computed tomography myocardial perfusion imaging Other: Oxygen 15 labelled water positron emission tomography

Detailed Description:
Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Outpatients with suspected coronary heart disease

Inclusion Criteria:

  • suspected coronary artery disease

Exclusion Criteria:

  • inability or unwillingness to undergo CT or PET imaging
  • renal failure (serum creatinine >200 um/L or eGFR <30 ml/min)
  • hepatic failure
  • allergy to iodinated contrast
  • pregnancy
  • contraindication to adenosine
  • inability to give informed consent
  • atrial fibrillation with a fast ventricular rate (>70 beats per minute)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01805193

Contact: Michelle Williams, MBChB

United Kingdom
Clinical Research Imaging Centre Recruiting
Edinburgh, Scotland, United Kingdom
Contact: Michelle Williams, MBCHb   
Sponsors and Collaborators
University of Edinburgh
Principal Investigator: David Newby, PhD DM University of Edinburgh
  More Information

Responsible Party: University of Edinburgh Identifier: NCT01805193     History of Changes
Other Study ID Numbers: 12/SS/0078
Study First Received: February 4, 2013
Last Updated: March 4, 2013

Keywords provided by University of Edinburgh:
Coronary heart disease
computed tomography myocardial perfusion
positron emission tomography
oxygen 15 labelled water
myocardial perfusion
myocardial blood flow

Additional relevant MeSH terms:
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases processed this record on August 18, 2017