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Creatine Supplementation on Cognition in Children

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2013 by Bruno Gualano, University of Sao Paulo.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Bruno Gualano, University of Sao Paulo Identifier:
First received: February 27, 2013
Last updated: March 1, 2013
Last verified: February 2013
Creatine supplementation may improve cognitive function in elderly and vegetarian individuals. This study aims to investigate the role of creatine supplementation on cognitive function in healthy children.

Condition Intervention
Healthy Dietary Supplement: creatine supplementation Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Creatine Supplementation on Cognitive Function in Children

Resource links provided by NLM:

Further study details as provided by Bruno Gualano, University of Sao Paulo:

Primary Outcome Measures:
  • cognitive function [ Time Frame: 7 days ]
    assessed by a battery of cognitive tests as follows: colors and words attention test, controlled words association test, memory and figures learning, mental flexibility test and inhibitory control, digit span test, and intelligence quotient.

Secondary Outcome Measures:
  • tissue creatine content [ Time Frame: 7 days ]
    as assessed by 1H-MRS.

Estimated Enrollment: 100
Study Start Date: February 2013
Estimated Study Completion Date: February 2015
Estimated Primary Completion Date: February 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: placebo
placebo (dextrose)
Dietary Supplement: Placebo
Experimental: creatine
creatine supplementation
Dietary Supplement: creatine supplementation
creatine supplementation


Ages Eligible for Study:   10 Years to 12 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy children
  • age between 10 to 12 years of age

Exclusion Criteria:

  • cognitive impairment
  • vegetarian diet
  • use of creatine in the past 6 months
  • chronic kidney disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01803230

Contact: Carlos Merege 551130913096

University of Sao Paulo Recruiting
Sao Paulo, Brazil
Contact: Carlos Merege    5511 30913096   
Principal Investigator: Bruno Gualano, Professor         
Sponsors and Collaborators
University of Sao Paulo
Principal Investigator: Bruno Gualano, Professor University of Sao Paulo
  More Information

Responsible Party: Bruno Gualano, Professor, University of Sao Paulo Identifier: NCT01803230     History of Changes
Other Study ID Numbers: Creatine in Children
Study First Received: February 27, 2013
Last Updated: March 1, 2013

Keywords provided by Bruno Gualano, University of Sao Paulo:
children processed this record on August 16, 2017