The Prognostic Assessment of Extubation in Aged Patients With Multiple Organ Dysfunction Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01802983
Recruitment Status : Unknown
Verified February 2013 by Kun Xiao, Chinese PLA General Hospital.
Recruitment status was:  Recruiting
First Posted : March 4, 2013
Last Update Posted : March 4, 2013
Information provided by (Responsible Party):
Kun Xiao, Chinese PLA General Hospital

Brief Summary:
The multiple organ dysfunction syndrome (MODS) has remained the major factor contributing to prolongation of intensive and mortality. It is reported that the mortality rates have varied between 20% and 100%, depending on number, severity, duration, type and combination, and definition of dysfunction. In our study, the investigators explore some comprehensive treatment technology to improved outcomes of MODS patients.

Condition or disease
Multiple Organ Dysfunction Syndrome

Study Type : Observational
Estimated Enrollment : 1 participants
Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Key Technology Research of the Comprehensive Treatment of Multiple Organ Dysfunction Syndrome
Study Start Date : January 2009
Estimated Primary Completion Date : December 2013
Estimated Study Completion Date : December 2013

Primary Outcome Measures :
  1. the prognostic assessment of aged patients with MODS [ Time Frame: 28 days ]
    According to the outcomes of 28-day,all the enrolled patients were divided into survival group and death group, clinical datum of which were collected and analysed. And then these prognosis were evaluated with the current scoring systems [(Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ, APACHE Ⅲ), Sample Acute Physiological score(SAPSⅡ), Multiple Organ Dysfunction score(MODS)], the predictive power of which were compared by receiver operating characteristic(ROC) curve. Finally, a binary logistic regression analysis was performed to evaluate the concerning prognostic factors of MODSE.

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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All subjects were selected from among inpatients who were hospitalized between Jan 2009 and May 2013 in the Respiratory Intensive Care Unit(RICU),Surgical Intensive Care Unit(SICU) and Emergency Intensive Care Unit(EICU).

Inclusion Criteria:

  • age > 60 years old;
  • presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention;
  • have trachea intubation after admitting to intensive care unit within 24 hours.

Exclusion Criteria:

  • end stage multiple organ failure.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01802983

Contact: Xiao Kun, doctor +8613716608331

China, Beijing
Chinese PLA General Hospital Recruiting
Beijing, Beijing, China, 100853
Contact: Xie Lixin, doctor    +86 010 55499130   
Sponsors and Collaborators
Chinese PLA General Hospital

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Kun Xiao, Key Technology Research of the comprehensive treatment of Multiple organ dysfunction syndrome, Chinese PLA General Hospital Identifier: NCT01802983     History of Changes
Other Study ID Numbers: 2013670808
First Posted: March 4, 2013    Key Record Dates
Last Update Posted: March 4, 2013
Last Verified: February 2013

Keywords provided by Kun Xiao, Chinese PLA General Hospital:
Multiple organ failure
invasive mechanical ventilation

Additional relevant MeSH terms:
Multiple Organ Failure
Pathologic Processes