The Natural History of Wheat Hypersensitivity in Thai Children
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Wheat allergy is affected 0.4-1% and is a major staple of the worldwide diet. Wheat avoidance is exceedingly difficult and imposes major dietary restriction. The purpose of this study were to determine the rate of oral tolerance and identify clinical and laboratory predictors of tolerance development in Thai children who allergic to wheat.
Condition or disease
Dietary Supplement: oral wheat challenge
All children in this study were sensitized to wheat. Each patient was clinically evaluated, with focus on wheat allergy by both a detailed medical examination and collection of medical history. Blood sample was taken for baseline determination of ImmunoglobulinE antibodies to wheat and to omega-5-gliadin. The oral wheat challenge were performed in all study subjects to identify a case of wheat outgrowing. The primary outcome was the development of oral tolerance to wheat. Oral wheat challenge were generally performed at least every 1 years if the child did not have an interval history of symptoms with unintentional exposure.
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Layout table for eligibility information
Ages Eligible for Study:
1 Year to 15 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
children 1 to 15 years
History of IgE-mediated wheat allergy
Parents refused to sign the consent
Patient has the underlying disease: congenital heart disease, uncontrolled asthma or life-threatening condition.