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Using NT-proBNP to Detect Chronic Heart Failure in Patients With Chronic Obstructive Pulmonary Disease (NT-proBNP)

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ClinicalTrials.gov Identifier: NCT01801722
Recruitment Status : Completed
First Posted : March 1, 2013
Last Update Posted : March 7, 2018
Sponsor:
Information provided by (Responsible Party):
Elzbieta Kaszuba, Lund University

Study Description
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Brief Summary:
The aim of the present study was to evaluate if the analysis of NT-proBNP might be used as an initial step for the diagnosis of chronic heart failure in patients with COPD in primary health care, and to select patients for a further examination by echocardiography.

Condition or disease
Chronic Obstructive Pulmonary Disease Chronic Heart Failure

Detailed Description:

Patients with a confirmed diagnosis of COPD were examined regarding chronic heart failure.

  1. An interview regarding symptoms: breathlessness, orthopnoea, night cough, nocturia, walking distance.
  2. Physical examination: weight and height, heart and lung auscultation, blood pressure measurement after 5 minutes' rest in the sitting position and the presence of peripheral oedema.
  3. Electrocardiography.
  4. Natriuretic peptide- NT-proBNP (Immulite 2500, Siemens Healthcare Diagnostics AB Sweden).
  5. Patients with the NT-proBNP level of > 1200 pg/ml were referred for echocardiography to assess left ventricular function.
Study Design
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Study Type : Observational
Actual Enrollment : 75 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Official Title: Using NT-proBNP to Detect Chronic Heart Failure in Patients With Chronic Obstructive Pulmonary Disease.
Study Start Date : April 2008
Actual Primary Completion Date : June 2008
Actual Study Completion Date : June 2008

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Groups and Cohorts
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Group/Cohort
NT-proBNP,ejection fraction ,COPD stage.
The group comprised 25 women (47%) and 28 men (53%). The mean age was 75.4 years (SD 7.9), 76.3 (SD 7.6) for men and 74.4 (SD 8.2) for women.


Outcome Measures
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Primary Outcome Measures :
  1. Percentage of patients with elevated NT-proBNP. [ Time Frame: 3 months ]
    NT-proBNP has taken only once in each patient without follow up follow up. Three months was a period when we collected data from all participants.


Secondary Outcome Measures :
  1. Percentage of patients with abnormal left ventricular function assessed by echocardiography. Association between elevated NT-proBNP and symptoms, signs and electrocardiography. [ Time Frame: 3 months ]
    Echocardiography was performed once in each referred patient. Three months was a period of data collection.


Eligibility Criteria
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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients aged 65 years and older with a registered diagnosis of COPD.
Criteria

Inclusion Criteria:

  • Patients aged 65 years and older with the following diagnosis codes according to International Statistical Classification of Diseases and Related Health Problems - Tenth Revision:J44 (COPD) and J41, J42 (chronic bronchitis) registered during the period 1 January 2008-16 April 2008 according to the electronic patient record.

Exclusion Criteria:

  • Impaired cognitive function and/or anticipated difficulties in carrying out spirometry due to immobility,
  • psychiatric disorders or terminal illness.
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01801722


Locations
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Sweden
Primary health care center.
Olofström, Blekinge, Sweden, 29332
Sponsors and Collaborators
Lund University
Investigators
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Principal Investigator: Elzbieta Kaszuba, PhD student Lund University
More Information
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Responsible Party: Elzbieta Kaszuba, PhD student, Lund University
ClinicalTrials.gov Identifier: NCT01801722    
Other Study ID Numbers: 502008
DN50/2008 ( Other Identifier: Ethics committee at Lund university )
First Posted: March 1, 2013    Key Record Dates
Last Update Posted: March 7, 2018
Last Verified: March 2018
Additional relevant MeSH terms:
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Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Heart Failure
 Heart Diseases
Cardiovascular Diseases
Respiratory Tract Diseases