Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm

This study has been terminated.

(Low enrollment)

Sponsor:

Information provided by (Responsible Party):

State University of New York - Upstate Medical University

ClinicalTrials.gov Identifier:

NCT01801488

First received: December 12, 2012

Last updated: November 24, 2015

Last verified: February 2013

History of Changes

Purpose

Test single nucleotide polymorphisms (SNP's) in ruptured and unruptured aneurysm tissue to identify a genetic difference between the two types of aneurysms; and to test SNP's in arteriovenous malformation tissue to identify a genetic link.

Condition
Arteriovenous Malformations Intracranial Aneurysm Subarachnoid Hemorrhage


Study Type:	Observational
Study Design:	Observational Model: Case Control Time Perspective: Prospective
Official Title:	Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm

Resource links provided by NLM:

MedlinePlus related topics: Aneurysms Arteriovenous Malformations Brain Aneurysm

U.S. FDA Resources

Further study details as provided by State University of New York - Upstate Medical University:

Primary Outcome Measures:

Risk gene expression [ Time Frame: Within one week of sample collection. ]
The samples will be frozen after collection and then analyzed.

Biospecimen Retention: Samples With DNA

Tissue samples of intracranial arterial-venous malformations (AVM) or aneurysm and blood samples.


Enrollment:	5
Study Start Date:	November 2011
Primary Completion Date:	March 2014 (Final data collection date for primary outcome measure)

Groups/Cohorts
AVM Patients Patients receiving surgical intervention for an intracranial arterial-venous malformation.
Ruptured Aneurysm Patients receiving surgical intervention for a ruptured intracranial aneurysm.
Unruptured Aneurysm Patients receiving surgical intervention for an unruptured intracranial aneurysm.

Eligibility


Ages Eligible for Study:	18 Years to 89 Years (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Patients admitted to University Hospital.

Criteria

Inclusion Criteria:

All adult patients between the ages of 18 and 89 that are having open surgical resection of an AVM or clipping of an aneurysm will be included

Exclusion Criteria:

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01801488

Locations


United States, New York
SUNY Upstate Medical University
Syracuse, New York, United States, 13210

Sponsors and Collaborators

State University of New York - Upstate Medical University

Investigators


Principal Investigator:	Eric M Deshaies, MD	SUNY Upstate Medical University Neurosurgery

More Information


Responsible Party:	State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:	NCT01801488 History of Changes
Other Study ID Numbers:	IRB#238810
Study First Received:	December 12, 2012
Last Updated:	November 24, 2015

Additional relevant MeSH terms:


Hemorrhage Aneurysm Subarachnoid Hemorrhage Congenital Abnormalities Intracranial Aneurysm Arteriovenous Malformations Hemangioma Pathologic Processes Vascular Diseases Cardiovascular Diseases Intracranial Hemorrhages	Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Intracranial Arterial Diseases Vascular Malformations Cardiovascular Abnormalities Neoplasms, Vascular Tissue Neoplasms by Histologic Type Neoplasms

ClinicalTrials.gov processed this record on July 19, 2017

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