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Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm

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ClinicalTrials.gov Identifier: NCT01801488
Recruitment Status : Terminated (Low enrollment)
First Posted : February 28, 2013
Last Update Posted : November 25, 2015
Sponsor:
Information provided by (Responsible Party):
State University of New York - Upstate Medical University

Study Description
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:
Test single nucleotide polymorphisms (SNP's) in ruptured and unruptured aneurysm tissue to identify a genetic difference between the two types of aneurysms; and to test SNP's in arteriovenous malformation tissue to identify a genetic link.

Condition or disease
Arteriovenous Malformations Intracranial Aneurysm Subarachnoid Hemorrhage

Study Design
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Study Type : Observational
Actual Enrollment : 5 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm
Study Start Date : November 2011
Actual Primary Completion Date : March 2014

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U.S. FDA Resources

Groups and Cohorts
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort
AVM Patients
Patients receiving surgical intervention for an intracranial arterial-venous malformation.
Ruptured Aneurysm
Patients receiving surgical intervention for a ruptured intracranial aneurysm.
Unruptured Aneurysm
Patients receiving surgical intervention for an unruptured intracranial aneurysm.


Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Risk gene expression [ Time Frame: Within one week of sample collection. ]
    The samples will be frozen after collection and then analyzed.


Biospecimen Retention:   Samples With DNA
Tissue samples of intracranial arterial-venous malformations (AVM) or aneurysm and blood samples.

Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients admitted to University Hospital.
Criteria

Inclusion Criteria:

  • All adult patients between the ages of 18 and 89 that are having open surgical resection of an AVM or clipping of an aneurysm will be included

Exclusion Criteria:

Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01801488


Locations
United States, New York
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Sponsors and Collaborators
State University of New York - Upstate Medical University
Investigators
Principal Investigator: Eric M Deshaies, MD SUNY Upstate Medical University Neurosurgery
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier: NCT01801488     History of Changes
Other Study ID Numbers: IRB#238810
First Posted: February 28, 2013    Key Record Dates
Last Update Posted: November 25, 2015
Last Verified: February 2013

Additional relevant MeSH terms:
Hemorrhage
Aneurysm
Subarachnoid Hemorrhage
Congenital Abnormalities
Intracranial Aneurysm
Arteriovenous Malformations
Hemangioma
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Intracranial Hemorrhages
 Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Intracranial Arterial Diseases
Vascular Malformations
Cardiovascular Abnormalities
Neoplasms, Vascular Tissue
Neoplasms by Histologic Type
Neoplasms