Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm
This study has been terminated.
(Low enrollment)
Sponsor:
State University of New York - Upstate Medical University
Information provided by (Responsible Party):
State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:
NCT01801488
First received: December 12, 2012
Last updated: November 19, 2014
Last verified: February 2013
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Purpose
Test single nucleotide polymorphisms (SNP's) in ruptured and unruptured aneurysm tissue to identify a genetic difference between the two types of aneurysms; and to test SNP's in arteriovenous malformation tissue to identify a genetic link.
| Condition |
|---|
|
Arteriovenous Malformations Intracranial Aneurysm Subarachnoid Hemorrhage |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm |
Resource links provided by NLM:
Genetics Home Reference related topics:
capillary malformation-arteriovenous malformation syndrome
Parkes Weber syndrome
U.S. FDA Resources
Further study details as provided by State University of New York - Upstate Medical University:
Primary Outcome Measures:
- Risk gene expression [ Time Frame: Within one week of sample collection. ] [ Designated as safety issue: No ]The samples will be frozen after collection and then analyzed.
Biospecimen Retention: Samples With DNA
Tissue samples of intracranial arterial-venous malformations (AVM) or aneurysm and blood samples.
| Enrollment: | 5 |
| Study Start Date: | November 2011 |
| Estimated Primary Completion Date: | November 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
AVM Patients
Patients receiving surgical intervention for an intracranial arterial-venous malformation.
|
|
Ruptured Aneurysm
Patients receiving surgical intervention for a ruptured intracranial aneurysm.
|
|
Unruptured Aneurysm
Patients receiving surgical intervention for an unruptured intracranial aneurysm.
|
Eligibility| Ages Eligible for Study: | 18 Years to 89 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Study Population
Patients admitted to University Hospital.
Criteria
Inclusion Criteria:
- All adult patients between the ages of 18 and 89 that are having open surgical resection of an AVM or clipping of an aneurysm will be included
Exclusion Criteria:
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01801488
Please refer to this study by its ClinicalTrials.gov identifier: NCT01801488
Locations
| United States, New York | |
| SUNY Upstate Medical University | |
| Syracuse, New York, United States, 13210 | |
Sponsors and Collaborators
State University of New York - Upstate Medical University
Investigators
| Principal Investigator: | Eric M Deshaies, MD | SUNY Upstate Medical University Neurosurgery |
More Information
No publications provided
| Responsible Party: | State University of New York - Upstate Medical University |
| ClinicalTrials.gov Identifier: | NCT01801488 History of Changes |
| Other Study ID Numbers: | IRB#238810 |
| Study First Received: | December 12, 2012 |
| Last Updated: | November 19, 2014 |
| Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Aneurysm Arteriovenous Malformations Congenital Abnormalities Hemangioma Intracranial Aneurysm Subarachnoid Hemorrhage Brain Diseases Cardiovascular Abnormalities Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders |
Hemorrhage Intracranial Arterial Diseases Intracranial Hemorrhages Neoplasms Neoplasms by Histologic Type Neoplasms, Vascular Tissue Nervous System Diseases Pathologic Processes Vascular Diseases Vascular Malformations |
ClinicalTrials.gov processed this record on March 01, 2015