Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm
This study has been terminated.
(Low enrollment)
Sponsor:
State University of New York - Upstate Medical University
Information provided by (Responsible Party):
State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:
NCT01801488
First received: December 12, 2012
Last updated: November 24, 2015
Last verified: February 2013
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Purpose
Test single nucleotide polymorphisms (SNP's) in ruptured and unruptured aneurysm tissue to identify a genetic difference between the two types of aneurysms; and to test SNP's in arteriovenous malformation tissue to identify a genetic link.
| Condition |
|---|
|
Arteriovenous Malformations Intracranial Aneurysm Subarachnoid Hemorrhage |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm |
Resource links provided by NLM:
Genetics Home Reference related topics:
Parkes Weber syndrome
capillary malformation-arteriovenous malformation syndrome
U.S. FDA Resources
Further study details as provided by State University of New York - Upstate Medical University:
Primary Outcome Measures:
- Risk gene expression [ Time Frame: Within one week of sample collection. ] [ Designated as safety issue: No ]The samples will be frozen after collection and then analyzed.
Biospecimen Retention: Samples With DNA
Tissue samples of intracranial arterial-venous malformations (AVM) or aneurysm and blood samples.
| Enrollment: | 5 |
| Study Start Date: | November 2011 |
| Primary Completion Date: | March 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
AVM Patients
Patients receiving surgical intervention for an intracranial arterial-venous malformation.
|
|
Ruptured Aneurysm
Patients receiving surgical intervention for a ruptured intracranial aneurysm.
|
|
Unruptured Aneurysm
Patients receiving surgical intervention for an unruptured intracranial aneurysm.
|
Eligibility| Ages Eligible for Study: | 18 Years to 89 Years (Adult, Senior) |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Study Population
Patients admitted to University Hospital.
Criteria
Inclusion Criteria:
- All adult patients between the ages of 18 and 89 that are having open surgical resection of an AVM or clipping of an aneurysm will be included
Exclusion Criteria:
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01801488
Please refer to this study by its ClinicalTrials.gov identifier: NCT01801488
Locations
| United States, New York | |
| SUNY Upstate Medical University | |
| Syracuse, New York, United States, 13210 | |
Sponsors and Collaborators
State University of New York - Upstate Medical University
Investigators
| Principal Investigator: | Eric M Deshaies, MD | SUNY Upstate Medical University Neurosurgery |
More Information
| Responsible Party: | State University of New York - Upstate Medical University |
| ClinicalTrials.gov Identifier: | NCT01801488 History of Changes |
| Other Study ID Numbers: | IRB#238810 |
| Study First Received: | December 12, 2012 |
| Last Updated: | November 24, 2015 |
| Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Hemorrhage Aneurysm Subarachnoid Hemorrhage Congenital Abnormalities Intracranial Aneurysm Arteriovenous Malformations Hemangioma Pathologic Processes Vascular Diseases Cardiovascular Diseases Intracranial Hemorrhages |
Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Intracranial Arterial Diseases Vascular Malformations Cardiovascular Abnormalities Neoplasms, Vascular Tissue Neoplasms by Histologic Type Neoplasms |
ClinicalTrials.gov processed this record on September 28, 2016