Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation?
|ClinicalTrials.gov Identifier: NCT01799655|
Recruitment Status : Completed
First Posted : February 27, 2013
Last Update Posted : May 6, 2014
Cardiovascular disease is the most common cause of mortality and morbidity worldwide. Recently, a growing body of evidence has identified Vitamin D deficiency as a potential risk factor for cardiovascular disease. Therefore, there is an increasing interest to explore the mechanism in which vitamin D deficiency affect the cardiovascular system.
The investigators want to examine the relationship between serum vitamin D levels and the coagulation status in the subjects. The applied the calibrated automated thrombogram (CAT) to assess thrombin generation in plasma as a measure of overall thrombotic activity, and thus to suggest a mechanism that may explain the link between vitamin D deficiency and cardiovascular disease.
Our study population are going to include 100 patients from the internal departments in Emek hospital, who present with chest pain but without acute coronary syndrome (ACS). The investigators will take blood samples from the subjects to measure the serum vitamin D levels and the generation of thrombin. The patients will be divided into four groups according to the level of vitamin D to evaluate the effect of vitamin D levels in the blood on coagulability and thrombotic activity in these patients.
|Condition or disease|
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||100 participants|
|Target Follow-Up Duration:||1 Day|
|Official Title:||Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation?|
|Study Start Date :||April 2013|
|Actual Primary Completion Date :||April 2014|
|Actual Study Completion Date :||April 2014|
U.S. FDA Resources
- thrombin generation levels and endogenous thrombin potentials [ Time Frame: 4 month ]measuring the thrombin generation and endogenous thrombin potential by the calibrated automated thrombogram (CAT)
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01799655
|Haemek medical center|
|Afula, Israel, 18101|
|Principal Investigator:||Mazen elias, prof||haemek medical center|