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Air Pollution, Inflammation and Acute Coronary Syndrome (AIRACOS)

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ClinicalTrials.gov Identifier: NCT01799148
Recruitment Status : Completed
First Posted : February 26, 2013
Last Update Posted : January 21, 2015
Sponsor:
Information provided by (Responsible Party):
Alberto Domínguez Rodríguez, Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Brief Summary:
The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of inflammatory molecules and oxidative stress. 2) To investigate whether the level of environmental exposure is an independent prognostic factor in terms of overall and cardiovascular mortality, myocardial infarction or unstable angina at 30 days, 6 and 12 months.

Condition or disease Intervention/treatment
Patients With Acute Coronary Syndrome Other: Particulate air pollutants

Study Type : Observational [Patient Registry]
Actual Enrollment : 307 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 360 Days
Official Title: Impact of AIR Pollution on Inflammation, Oxidative Stress and 1-year Prognosis in Patients Hospitalized for Acute COronary Syndrome
Study Start Date : November 2011
Actual Primary Completion Date : July 2014
Actual Study Completion Date : November 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Air Pollution

Group/Cohort Intervention/treatment
Particulate air pollutants
Cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission.
Other: Particulate air pollutants
We will determined the average concentrations of different sizes of particulate matter from 1 day or up to 7 days prior to admission in patients with acute coronary syndrome.




Primary Outcome Measures :
  1. Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome. [ Time Frame: 7 days ]
    A single center, cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission. Also be determined inflammatory molecules and oxidative stress in admission.


Secondary Outcome Measures :
  1. Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome. [ Time Frame: 1 year ]
    During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.


Other Outcome Measures:
  1. Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome: [ Time Frame: 1 year ]
    During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.



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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Cohort of consecutive patients admitted with diagnosis of aucte coronary, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission. Also be determined inflammatory molecules and oxidative stress in admission. During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles, in all patients included at 30 days, 6 and 12 months.
Criteria

Inclusion Criteria:

  • Patients with acute coronary syndrome

Exclusion Criteria:

  • Infectious process and / or local or systemic inflammation in the 15 days before admission.
  • Thyrotoxicosis.
  • Neoplasms - or any other disease that seriously compromise the prognosis of life and / or generate a systemic inflammatory response.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01799148


Locations
Spain
Hospital Universitario de Canarias
La Laguna, Santa Cruz de Tenerife, Spain, E-38320
Sponsors and Collaborators
Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Alberto Domínguez Rodríguez, Alberto Dominguez Rodriguez, Fundación Canaria Rafael Clavijo para la Investigación Biomédica
ClinicalTrials.gov Identifier: NCT01799148     History of Changes
Other Study ID Numbers: AIRACOS
AIRACOS-CANARY ISLANDS ( Other Identifier: Hospital Universitario de Canarias )
First Posted: February 26, 2013    Key Record Dates
Last Update Posted: January 21, 2015
Last Verified: January 2015

Keywords provided by Alberto Domínguez Rodríguez, Fundación Canaria Rafael Clavijo para la Investigación Biomédica:
Acute coronary syndrome
Air pollution.
Inflammation.
Oxidative Stress.
Prognosis

Additional relevant MeSH terms:
Syndrome
Inflammation
Acute Coronary Syndrome
Disease
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases