Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca
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|ClinicalTrials.gov Identifier: NCT01797822|
Recruitment Status : Completed
First Posted : February 25, 2013
Last Update Posted : January 26, 2016
The purpose of this study is to evaluate whether, in people with dry eye syndrome, over the counter artificial tears and the prescription eye drop, dexamethasone, change or effect the eyes response to a low humidity environment.
It is known that irritation from dry eye can be improved by over the counter artificial tears because they wet and lubricate the eyes. The prescription eye drop, dexamethasone, can also improve eye irritation by decreasing the inflammation that develops in dry eye. Thus, the investigators hypothesize that the use of these conventional dry eye treatments will improve the eyes' response to a low humidity environment.
|Condition or disease||Intervention/treatment||Phase|
|Keratoconjunctivitis Sicca Dry Eye Syndrome||Drug: dexamethasone, artificial tears||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||4 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca.|
|Study Start Date :||February 2013|
|Actual Primary Completion Date :||December 2015|
|Actual Study Completion Date :||December 2015|
Dexamethasone, artificial tears
Dexamethasone 0.01% ophthalmic solution four times a day for two weeks in both eyes Artificial tears four times a day for two weeks in both eyes
|Drug: dexamethasone, artificial tears|
- Changes in ocular surface measured by routine opthalmic dyes [ Time Frame: Two weeks after treatment and exposure to a low humidity environment ]Subjects will be exposed to a low humidity environment at initial examination and then after two weeks of using artificial tears, and lastly after two weeks of using dexamethasone. The changes in the ocular surface will be measured after each exposure to a low humidity environment.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01797822
|United States, Texas|
|Baylor College of Medicine, Alkek Eye Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Stephen Pflugfelder, MD||Baylor College of Medicine|