Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca
The purpose of this study is to evaluate whether, in people with dry eye syndrome, over the counter artificial tears and the prescription eye drop, dexamethasone, change or effect the eyes response to a low humidity environment.
It is known that irritation from dry eye can be improved by over the counter artificial tears because they wet and lubricate the eyes. The prescription eye drop, dexamethasone, can also improve eye irritation by decreasing the inflammation that develops in dry eye. Thus, the investigators hypothesize that the use of these conventional dry eye treatments will improve the eyes' response to a low humidity environment.
Dry Eye Syndrome
Drug: dexamethasone, artificial tears
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effects of Conventional Dry Eye Treatments on the Ocular Surface Response to Low Humidity Environment in Patients With Keratoconjunctivitis Sicca.|
- Changes in ocular surface measured by routine opthalmic dyes [ Time Frame: Two weeks after treatment and exposure to a low humidity environment ] [ Designated as safety issue: No ]Subjects will be exposed to a low humidity environment at initial examination and then after two weeks of using artificial tears, and lastly after two weeks of using dexamethasone. The changes in the ocular surface will be measured after each exposure to a low humidity environment.
|Study Start Date:||February 2013|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Dexamethasone, artificial tears
Dexamethasone 0.01% ophthalmic solution four times a day for two weeks in both eyes Artificial tears four times a day for two weeks in both eyes
|Drug: dexamethasone, artificial tears|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01797822
|Contact: Karri Schuetzle, COA, CCRPfirstname.lastname@example.org|
|United States, Texas|
|Baylor College of Medicine, Alkek Eye Center||Recruiting|
|Houston, Texas, United States, 77030|
|Contact: Karri Schuetzle, AAS, COA, CCRP email@example.com|
|Principal Investigator: Stephen Pflugfelder, MD|
|Principal Investigator:||Stephen Pflugfelder, MD||Baylor College of Medicine|