Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients (GLUPTEN)
Recruitment status was: Recruiting
Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood. The Phosphatase and Tensin homolog (PTEN) is known to influence glucose homeostasis by interfering in intracellular insulin signaling.
Aim of this study is to ascertain whether differential expression of PTEN in critically ill patients correlates with glycemic variability and clinical outcome.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Influence of PTEN on Glycemic Variability and Clinical Outcome in the Critically Ill Patient.|
- Length of ICU stay [ Time Frame: Day 1 up to day 28 ] [ Designated as safety issue: No ]
- Glycemic variability as expressed by standard deviation of the glycemia measurements [ Time Frame: Day 1 up to day 28 ] [ Designated as safety issue: No ]
|Study Start Date:||December 2012|
|Estimated Study Completion Date:||December 2014|
|Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01796847
|University of Rome La Sapienza, University Hospital|
|Rome, Italy, 00185|
|Principal Investigator:||Alessandro Laviano, MD||Sapienza University of Rome|