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Accuracy of the Pleth Variability Index to Predict Fluid Responsiveness in Liver Transplantation

This study has been completed.
Information provided by (Responsible Party):
Gulay ERDOGAN KAYHAN, Inonu University Identifier:
First received: February 8, 2013
Last updated: February 13, 2013
Last verified: February 2013
The aim of this study is to compare the accuracy of PVI (pleth variability index)

Condition Intervention Phase
Hemodynamic Instability
Device: PVI-guided fluid management
Phase 4

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Accuracy and Utility of the Pleth Variability Index as a Predictor of Fluid Responsiveness During the Dissection and Anhepatic Phase of Liver Transplantation

Resource links provided by NLM:

Further study details as provided by Gulay ERDOGAN KAYHAN, Inonu University:

Primary Outcome Measures:
  • To test the ability of PVI to detect changes in preload during orthotopic liver transplantation [ Time Frame: During dissection and anhepatic phase (3 months) ]
    PVI is a measure of the dynamic changes in perfusion index that occur during a complete respiratory cycle

Enrollment: 25
Study Start Date: October 2012
Study Completion Date: February 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: PVI
A new non-invasive device (Radical-7 pulse oximeter monitor, Masimo Corp.) has been introduced that continuously detects changes in the plethysmograph waveform and computes a Plethysmography Variability Index (PVI) reflecting alteration in preload and fluid management.
Device: PVI-guided fluid management
In this study of 25 adult patients undergoing OLT, we prospectively record PVIwithin 5 minutes during dissection and anhepatic phase of OLT by Masimo pulse oximeter.In this study of 25 adult patients undergoing OLT, we prospectively record study data within 5 minutes during dissection and anhepatic phase of OLT. Study data included measurements of PVI,thermodilution cardiac output, Stroke volume variation (SVV) and Pulse pressure variation (PPV).

Detailed Description:
The aim of this study is to compare the accuracy of PVI (pleth variability index)with other hemodynamic variability that measured with PİCCO (SVV, PPV, CVP,CI)to predict the response of cardiac index to volume replacement in patients undergoing liver transplantation.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Elective living donor liver transplantation,
  • >18 years patients

Exclusion Criteria:

Patients with:

  • Arrhythmia
  • Reduced left ventricular function (EF<40%)
  • Hepatocellular carcinoma
  • Pulmonary hypertension
  • Fulminant liver failure
  • valvular heart disease
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Please refer to this study by its identifier: NCT01792011

Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation
Malatya, Turkey, 44315
Sponsors and Collaborators
Inonu University
Study Chair: Gulay Erdogan Kayhan, Dr Inonu University Faculty of Medicine Anesthesiology and Reanimation Department
  More Information

Responsible Party: Gulay ERDOGAN KAYHAN, MD,Asistant Professor Dr, Inonu University Identifier: NCT01792011     History of Changes
Other Study ID Numbers: Institute of LLT
Study First Received: February 8, 2013
Last Updated: February 13, 2013

Keywords provided by Gulay ERDOGAN KAYHAN, Inonu University:
Elective living donor liver transplantation processed this record on May 25, 2017