Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening
|Postural Tachycardia Syndrome||Other: Autonomic Function Testing Other: Posture Study Procedure: Measurement of Total Blood Volume Other: Exercise Capacity Test|
|Study Design:||Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Screening
|Official Title:||Aldosterone and Sodium Regulation in Postural Tachycardia Syndrome - Screening Protocol|
- blood volume deviation (%) from individual predicted volumes [ Time Frame: 2 days ]Compare blood volume deviations using the 131-I-Albumin method. Deviations will be reported as a percentage deviation from an individual's predicted value. These values will be compared between POTS patients and healthy control groups.
|Study Start Date:||February 2013|
|Estimated Study Completion Date:||February 2018|
|Estimated Primary Completion Date:||February 2018 (Final data collection date for primary outcome measure)|
All participants will be administered all procedures as described previously.
Autonomic Function Testing, Posture Study ,Measurement of Total Blood Volume ,Exercise Capacity Test
Other: Autonomic Function Testing
Other: Posture Study
heart rate and blood pressure will be continuously monitored while participants undergo a variety of breathing techniques (deep breathing, rapid breathing, blowing against resistance) and during sustained handgrip and cold pressor (hand in ice water). All tests are meant to stimulate the autonomic nervous system to produce changes in blood pressure and heart rate of short duration that reflect how well the autonomic nervous system is functioning.
Also during autonomic function testing, cardiac output will be measured to analyze the shift of fluids in the body (body impedance) and / or by analyzing the air that is breathed.
Blood pressure, heart rate and blood samples (for catecholamines and hormones) will be measured & collected in the supine (lying) and upright position for each participant.
Other Name: Supine & standing blood pressure, heart rate & blood draws.Procedure: Measurement of Total Blood Volume
Total blood volume is measured by using iodinated I-131 tagged human serum albumin.
Other Names:Other: Exercise Capacity Test
Participants will ride on a stationary recumbent bicycle and the resistance will be gradually increased while expired air is measured.
Other Name: Masimal Oxygen Consumption Test
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01783288
|United States, Tennessee|
|Vanderbilt University Medical Center|
|Nashville, Tennessee, United States, 37232|
|Principal Investigator:||Emily Garland, PhD, MSCI||Vanderbilt University Medical Center|