Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments
The beneficial effect of nocturnal sleep on memory consolidation is well-documented in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. Recent evidence in young healthy subjects suggest that the sleep-associated consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during SWS. If patients with amnestic mild cognitive impairments (MCI)- usually characterized by initial difficulties in hippocampus dependent memory functions - benefit from transcranial slow oscillatory stimulation (tSOS) during nocturnal sleep as well has not been studied so far. The primary aim of the present study is to investigate the influence of a weak slow oscillating brain stimulation (tSOS) on declarative memory consolidation applied during periods of nocturnal SWS in MCI patients.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
|Official Title:||Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Nocturnal Slow Wave Sleep in Patients With Mild Cognitive Impairments(MCI)|
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
- Amount of Slow wave Sleep, spindels, eeg-correlates, further memory systems [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
- Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
|Study Start Date:||April 2013|
|Estimated Study Completion Date:||June 2015|
|Estimated Primary Completion Date:||May 2015 (Final data collection date for primary outcome measure)|
Experimental: 0,75 Hz stimulation
slow transcranial oscillating stimulation (~0,75Hz) during periods of Slow Wave Sleep
Other Name: oscillating direct current brain stimulation
Sham Comparator: SHAM stimulation
SHAM stimulation during periods of Slow Wave Sleep
Please refer to this study by its ClinicalTrials.gov identifier: NCT01782391
|Contact: Sven Paßmann, M.sc.||030/450 560 firstname.lastname@example.org|
|Contact: Nadine Külzow, PhD||030/450 560 email@example.com|
|Charite CCM Neurologie Berlin||Recruiting|
|Berlin, Germany, 10117|
|Contact: Sven Paßmann, M.sc. +49/30/450560395 firstname.lastname@example.org|
|Contact: Agnes Flöel, Prof. Dr. +49/30/450560284 email@example.com|
|Sub-Investigator: Nadine Külzow, Dr.|
|Sub-Investigator: Sven Paßmann, M.sc.|
|Principal Investigator: Agnes Flöel, Prof. Dr.|
|Study Chair:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|