Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01782391|
Recruitment Status : Recruiting
First Posted : February 1, 2013
Last Update Posted : December 21, 2016
|Condition or disease||Intervention/treatment|
|Mild Cognitive Impairment, So Stated||Device: Stimulation Device: SHAM|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||22 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Nocturnal Slow Wave Sleep in Patients With Mild Cognitive Impairments(MCI)|
|Study Start Date :||April 2013|
|Estimated Primary Completion Date :||December 2017|
|Estimated Study Completion Date :||December 2017|
Experimental: 0,75 Hz stimulation
slow transcranial oscillating stimulation (~0,75Hz) during periods of Slow Wave Sleep
Other Name: oscillating direct current brain stimulation
Sham Comparator: SHAM stimulation
SHAM stimulation during periods of Slow Wave Sleep
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [ Time Frame: 4 weeks ]Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
- Amount of Slow wave Sleep, spindels, eeg-correlates, further memory systems [ Time Frame: 4 weeks ]
- Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01782391
|Contact: Sven Paßmann, M.sc.||030/450 560 email@example.com|
|Contact: Nadine Külzow, PhD||030/450 560 firstname.lastname@example.org|
|Charite CCM Neurologie Berlin||Recruiting|
|Berlin, Germany, 10117|
|Contact: Sven Paßmann, M.sc. +49/30/450560395 email@example.com|
|Contact: Agnes Flöel, Prof. Dr. +49/30/450560284 firstname.lastname@example.org|
|Sub-Investigator: Nadine Külzow, Dr.|
|Sub-Investigator: Sven Paßmann, M.sc.|
|Principal Investigator: Agnes Flöel, Prof. Dr.|
|Study Chair:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|