Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments
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|ClinicalTrials.gov Identifier: NCT01782391|
Recruitment Status : Recruiting
First Posted : February 1, 2013
Last Update Posted : December 21, 2016
|Condition or disease||Intervention/treatment||Phase|
|Mild Cognitive Impairment, So Stated||Device: Stimulation Device: SHAM||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||22 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Nocturnal Slow Wave Sleep in Patients With Mild Cognitive Impairments(MCI)|
|Study Start Date :||April 2013|
|Estimated Primary Completion Date :||December 2017|
|Estimated Study Completion Date :||December 2017|
Experimental: 0,75 Hz stimulation
slow transcranial oscillating stimulation (~0,75Hz) during periods of Slow Wave Sleep
Other Name: oscillating direct current brain stimulation
Sham Comparator: SHAM stimulation
SHAM stimulation during periods of Slow Wave Sleep
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [ Time Frame: 4 weeks ]Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
- Amount of Slow wave Sleep, spindels, eeg-correlates, further memory systems [ Time Frame: 4 weeks ]
- Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01782391
|Contact: Sven Paßmann, M.sc.||030/450 560 firstname.lastname@example.org|
|Contact: Nadine Külzow, PhD||030/450 560 email@example.com|
|Charite CCM Neurologie Berlin||Recruiting|
|Berlin, Germany, 10117|
|Contact: Sven Paßmann, M.sc. +49/30/450560395 firstname.lastname@example.org|
|Contact: Agnes Flöel, Prof. Dr. +49/30/450560284 email@example.com|
|Sub-Investigator: Nadine Külzow, Dr.|
|Sub-Investigator: Sven Paßmann, M.sc.|
|Principal Investigator: Agnes Flöel, Prof. Dr.|
|Study Chair:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|