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Branched Chain Amino Acid Plus Glucose Supplement Reduces Exercise-Induced Delayed Onset Muscle Soreness in College Females

This study has been completed.
Information provided by (Responsible Party):
Stephen J. Pintauro, University of Vermont Identifier:
First received: January 30, 2013
Last updated: January 31, 2013
Last verified: January 2013
The purpose of this study is to determine if a dietary supplement containing branched chain amino acids will reduce the muscle soreness that sometimes occurs in the days following exercise.

Condition Intervention
Exercise-induced Delayed Onset Muscle Soreness Dietary Supplement: Branched Chain Amino Acid drink supplement Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: The Effects of Branched Chain Amino Acid and Nutrient Supplementation on Exercise-Induced Delayed Onset Muscle Soreness in College Females

Resource links provided by NLM:

Further study details as provided by Stephen J. Pintauro, University of Vermont:

Primary Outcome Measures:
  • Delayed Onset Muscle Soreness Rating Scale [ Time Frame: Every 24 hours for four days following exercise ]

Enrollment: 20
Study Start Date: September 2011
Primary Completion Date: November 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Branch Chain Amino Acid supplement
A drink supplement containing 1.22 grams of branched chain amino acids, plus glucose.
Dietary Supplement: Branched Chain Amino Acid drink supplement
Placebo Comparator: Placebo supplement
The placebo was formulated to match both the taste and color of the test supplement. Crystal Light Lemonade powder (Kraft Foods, Northfield, IL, USA) was mixed with 5.6g of powdered dextrose (Now Foods, Bloomingdale, IL, USA) to match the amount of dextrose present in the BCAA supplement.
Dietary Supplement: Placebo

Detailed Description:
Supplementation with branched chain amino acids (BCAAs) has been used to stimulate muscle protein synthesis following exercise. The purpose of this study was to determine if supplementation with BCAAs in combination with glucose would reduce exercise-induced delayed onset muscle soreness (DOMS). Using a double-blind crossover design, 20 subjects (11 females, 9 males) were randomly assigned to either BCAA (n=10) or placebo (n=10) groups. Subjects performed a squatting exercise to elicit DOMS and rated their muscle soreness every 24 hours for four days following exercise while continuing to consume the BCAA or placebo. Following a three-week recovery period, subjects returned and received the alternate BCAA or placebo treatment, repeating the same exercise and DOMS rating protocol for the next four days. BCAA supplementation in female subjects resulted in a significant decrease in DOMS versus placebo at 24 hours following exercise (p = 0.018). No significant effect of BCAA supplementation versus placebo was noted in male subjects, nor when male and female results were analyzed together. This gender difference may be related to dose per body weight differences between male and female subjects.

Ages Eligible for Study:   18 Years to 25 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Men (n=9) and women (n=11) aged 18-25 who engaged in no more than one hour of light to moderate intensity physical activity per week were recruited from the Greater Burlington, Vermont area.

Exclusion Criteria:

  • individuals who engaged in more than one hour per week of light to moderate physical activity
  • had been involved in strict athletic competition or weight training in the past six months
  • were pregnant or nursing, had a known muscular disease, diabetes mellitus, cardiovascular disease, respiratory disease, and/or were currently taking a protein-based dietary supplement
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Please refer to this study by its identifier: NCT01781910

United States, Vermont
University of Vermont
Burlington, Vermont, United States, 05405
Sponsors and Collaborators
University of Vermont
Principal Investigator: Stephen J Pintauro, Ph.D. University of Vermont
  More Information

Responsible Party: Stephen J. Pintauro, Associate Professor, University of Vermont Identifier: NCT01781910     History of Changes
Other Study ID Numbers: CHRMS M12-101
Study First Received: January 30, 2013
Last Updated: January 31, 2013

Keywords provided by Stephen J. Pintauro, University of Vermont:
branched chain amino acids, exercise, delayed onset muscle soreness

Additional relevant MeSH terms:
Muscular Diseases
Musculoskeletal Diseases
Musculoskeletal Pain
Neurologic Manifestations
Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms processed this record on September 21, 2017