We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Changes in Metabolic Status in Patients With Total Thyroidectomy (Thyroid cancer)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01781767
Recruitment Status : Unknown
Verified January 2013 by Tel-Aviv Sourasky Medical Center.
Recruitment status was:  Recruiting
First Posted : February 1, 2013
Last Update Posted : February 1, 2013
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).

Condition or disease
Thyroid Cancer

Detailed Description:
Blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.

Study Design

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : January 2013
Estimated Primary Completion Date : July 2014
Estimated Study Completion Date : July 2014

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Primary Outcome Measures :
  1. Changes in UCP2 mRNA concentrations. [ Time Frame: Base line (before opporation), 2 weeks after opporation and for after opporation. ]
    The difference between the result at two weeks and four months compare to base line.


Secondary Outcome Measures :
  1. Weight [ Time Frame: Approximately 4 months ]
  2. Resting energy expenditure [ Time Frame: Approximatly 4 months ]

Biospecimen Retention:   Samples Without DNA
Whole blood for UCP2 mRNA

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients who were diagnosed with thyroid carcinoma and are going throgh total thyroidectomy and recive a thyroid replacement therapy.
Criteria

Inclusion Criteria:

  • Patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy.
  • Patients with unbalanced thyroid hormones.
  • Aged 18-65 years at the time of screening.
  • Provision of written informed consent.

Exclusion Criteria:

  • Patients with Diabetes.
  • Patients with any other chronic inflammatory diseases.
  • Steroid treatment.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01781767


Contacts
Contact: Nachum Vaisman, M.D. 972-3-6974807 vaisman@tasmc.health.gov.il

Locations
Israel
Tel Aviv Sourasky Medical Center Recruiting
Tel Aviv, Israel, 64239
Contact: Nachum Vaisman, M.D.    972-3-6974807    vaisman@tasmc.health.gov.il   
Sponsors and Collaborators
Tel-Aviv Sourasky Medical Center