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Changes in Metabolic Status in Patients With Total Thyroidectomy (Thyroid cancer)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2013 by Tel-Aviv Sourasky Medical Center.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Tel-Aviv Sourasky Medical Center Identifier:
First received: January 27, 2013
Last updated: January 30, 2013
Last verified: January 2013
This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).

Thyroid Cancer

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Tel-Aviv Sourasky Medical Center:

Primary Outcome Measures:
  • Changes in UCP2 mRNA concentrations. [ Time Frame: Base line (before opporation), 2 weeks after opporation and for after opporation. ]
    The difference between the result at two weeks and four months compare to base line.

Secondary Outcome Measures:
  • Weight [ Time Frame: Approximately 4 months ]
  • Resting energy expenditure [ Time Frame: Approximatly 4 months ]

Biospecimen Retention:   Samples Without DNA
Whole blood for UCP2 mRNA

Estimated Enrollment: 50
Study Start Date: January 2013
Estimated Study Completion Date: July 2014
Estimated Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Detailed Description:
Blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients who were diagnosed with thyroid carcinoma and are going throgh total thyroidectomy and recive a thyroid replacement therapy.

Inclusion Criteria:

  • Patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy.
  • Patients with unbalanced thyroid hormones.
  • Aged 18-65 years at the time of screening.
  • Provision of written informed consent.

Exclusion Criteria:

  • Patients with Diabetes.
  • Patients with any other chronic inflammatory diseases.
  • Steroid treatment.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01781767

Contact: Nachum Vaisman, M.D. 972-3-6974807

Tel Aviv Sourasky Medical Center Recruiting
Tel Aviv, Israel, 64239
Contact: Nachum Vaisman, M.D.    972-3-6974807   
Sponsors and Collaborators
Tel-Aviv Sourasky Medical Center
  More Information

Responsible Party: Tel-Aviv Sourasky Medical Center Identifier: NCT01781767     History of Changes
Other Study ID Numbers: TASMC-12-NV-376-CTIL
Study First Received: January 27, 2013
Last Updated: January 30, 2013

Keywords provided by Tel-Aviv Sourasky Medical Center:
Thyroid function
Thyroid carcinoma

Additional relevant MeSH terms:
Thyroid Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Head and Neck Neoplasms
Endocrine System Diseases
Thyroid Diseases processed this record on May 25, 2017