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Investigation of Anatomical Correlates of Speech Discrimination

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2016 by Steward St. Elizabeth's Medical Center of Boston, Inc.
Information provided by (Responsible Party):
Mark Parker, Steward St. Elizabeth's Medical Center of Boston, Inc. Identifier:
First received: January 29, 2013
Last updated: November 23, 2016
Last verified: November 2016
Understanding speech is essential for good communication. Individuals with hearing loss and poor speech discrimination often have little success with hearing aids because amplifying sound improves audibility, but not clarity of the speech signal. The purpose of this study is to determine the relative importance of the sensory cells of the inner ear and auditory neurons on speech discrimination performance in quiet and in noise. This information may be used as a predictor of hearing aid benefit. The investigators expect to find decreased speech understanding ability resulting from both loss of sensory cells and the loss of auditory neurons.

Sensorineural Hearing Loss

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional

Resource links provided by NLM:

Further study details as provided by Steward St. Elizabeth's Medical Center of Boston, Inc.:

Primary Outcome Measures:
  • Regression analysis [ Time Frame: February 2014 ]
    Regression analysis will be used to look for a correlation between measures of sensory cell and auditory neuron survival and speech recognition performance.

Estimated Enrollment: 100
Study Start Date: January 2013
Estimated Study Completion Date: August 2019
Estimated Primary Completion Date: January 2019 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 100 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adult patients referred from the St. Elizabeth's Department of Otolaryngology and self-referred patients to the Audiology Clinic.

Inclusion Criteria:

  • Normal hearing to moderate sensorineural hearing loss
  • Sufficient English proficiency to complete speech discrimination testing in English

Exclusion Criteria:

  • Hearing loss less than a 45 dB HL pure tone average (average hearing thresholds at 500, 1000 and 2000 Hz)
  • Conductive hearing loss
  • Neurodegenerative disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01781039

United States, Massachusetts
Steward St. Elizabeth's Medical Center Recruiting
Brighton, Massachusetts, United States, 02135
Contact: Mark Parker, PhD    617-779-7956   
Sub-Investigator: Naomi Bramhall, PhD         
Sub-Investigator: Michael Dybka, PhD         
Principal Investigator: Mark Parker, PhD         
Sponsors and Collaborators
Steward St. Elizabeth's Medical Center of Boston, Inc.
Principal Investigator: Mark Parker, PhD Steward St. Elizabeth's Medical Center
  More Information

Additional Information:
Responsible Party: Mark Parker, Director of Audiology, St. Elizabeth's Medical Center, Steward St. Elizabeth's Medical Center of Boston, Inc. Identifier: NCT01781039     History of Changes
Other Study ID Numbers: 00652
Study First Received: January 29, 2013
Last Updated: November 23, 2016

Keywords provided by Steward St. Elizabeth's Medical Center of Boston, Inc.:
"hair cell"
"spiral ganglion"
"hearing aid"
"hearing loss"

Additional relevant MeSH terms:
Hearing Loss
Hearing Loss, Sensorineural
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on April 25, 2017