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Cerebral Reorganization in Schizophrenia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01781000
First Posted: January 31, 2013
Last Update Posted: November 4, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Prof. Dr. Brigitte Rockstroh, University of Konstanz
  Purpose
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia

Condition Intervention
Schizophrenia Behavioral: Brain Fitness & Brain Training- Posit Science Behavioral: Facial Affect Training- FAT Behavioral: Treatment as usual

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Training-induced Cerebral Reorganization in Schizophrenia

Resource links provided by NLM:


Further study details as provided by Prof. Dr. Brigitte Rockstroh, University of Konstanz:

Primary Outcome Measures:
  • change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations [ Time Frame: baseline, post-intervention (after 4 weeks), 3-months follow-up ]

Secondary Outcome Measures:
  • change from baseline in global functioning (GAF score) at 4 weeks and 3 months [ Time Frame: baseline, post-intervention, 3-months follow-up ]

Enrollment: 80
Study Start Date: December 2011
Study Completion Date: April 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Auditiory verbal discrimination training
Brain Fitness & Brain Training- Posit Science
Behavioral: Brain Fitness & Brain Training- Posit Science
Computer aided cognitive program designed for intensive training of auditory perception, memory and attention
Experimental: Facial affect discrimination training
Behavioral: Facial Affect Training- FAT
Behavioral: Facial Affect Training- FAT
Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention
Active Comparator: Treatment as usual
standard treatment/rehabilitation protocol of schizophrenia ward
Behavioral: Treatment as usual
standard treatment protocol of schizophrenia ward

Detailed Description:
Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of schizophrenia and disorders with psychotic features
  • Intact auditory perception
  • Intact visual perception

Exclusion Criteria:

  • Mental retardation
  • Age over 60
  • Insufficient German language knowledge
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01781000


Locations
Germany
University of Konstanz
Konstanz, Baden Württemberg, Germany, 78464
Sponsors and Collaborators
University of Konstanz
Investigators
Study Chair: Brigitte Rockstroh, Prof. Dr. University Konstanz
  More Information

Additional Information:
Publications:
Responsible Party: Prof. Dr. Brigitte Rockstroh, Prof. Dr., University of Konstanz
ClinicalTrials.gov Identifier: NCT01781000     History of Changes
Other Study ID Numbers: RO805/142
First Submitted: January 22, 2013
First Posted: January 31, 2013
Last Update Posted: November 4, 2014
Last Verified: November 2014

Keywords provided by Prof. Dr. Brigitte Rockstroh, University of Konstanz:
Cognitive Training
Neuroplasticity
MEG
MATRICS

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders