Relationship Between Vestibular Function and Topographic Memory
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01780896
Verified January 2013 by Biomedical Development Corporation. Recruitment status was: Not yet recruiting
: January 31, 2013
Last Update Posted
: February 1, 2013
Biomedical Development Corporation
National Center for Advancing Translational Science (NCATS)
The purpose of this study is to evaluate visual and nonvisual topographic memory impairment and its relationship to vestibular function in humans. Topographic memory refers to the ability to remember current and past locations in topographic (navigational) space and to make and/or adjust to spatial transformations using such memories. Performance on each of these topographic memory tasks will be compared to performance on a set of comparable nontopographic memory tasks. Topographic impairments represent some of the earliest cognitive deficits observed in Alzheimer's Disease, and the brain areas involved in topographic memory are the first to show degenerative changes.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
70 Years to 85 Years (Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Nominally healthy adults between the ages of 70 and 85 yrs who meet inclusion/exclusion criteria. All study participants will be recruited from the San Antonio community.
Males or females of all racial and ethnic groups between the ages of 70 and 85 years of age;
Montreal Cognitive Assessment (MOCA) (http://www.mocatest.org) score of >24;
No known history or current evidence of stroke, trauma, psychiatric illness, or other insult to the brain;
No current use of psychoactive medicine other than caffeine (100 mg/day) or alcohol (1-2 drinks per night);
Normal sleep (at least an average of 7 hours for four days prior to participation);
Able and willing to comply with study requirements including following instructions to complete vestibular and neuropsychological testing; and
Have full understanding of all elements of provide signature and dating of the written informed consent prior to the initiation of procedures specified in protocol.
<70 or >85 yrs of age;
MOCA score of <25;
History, or current evidence, of stroke, trauma, psychiatric illness, or other insult to the brain;
Prior history of inner-ear balance problems;
Current use of psychoactive medicine other than moderate caffeine or alcohol use;
Acute or chronic sleep deprivation during the week prior to participation (<7 hours/night on average for four nights prior to participation).
No alcohol use on the night before the vestibular testing
7 hours minimum sleep the night before vestibular testing
No eye make-up can be worn on the day of the vestibular test due to possible interference with vestibular-ocular reflex testing apparatus