The Effects of Two Endometrium Preparation Protocols in Frozen-thawed Embryo Transfer in Women With Irregular Cycles
|ClinicalTrials.gov Identifier: NCT01780610|
Recruitment Status : Unknown
Verified March 2013 by Qingxue Zhang, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University.
Recruitment status was: Recruiting
First Posted : January 31, 2013
Last Update Posted : April 2, 2013
|Condition or disease||Intervention/treatment||Phase|
|Infertility||Drug: Letrozole and human chorionic gonadotrophin Drug: estradiol and progesterone||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||670 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||The Effects of Two Endometrium Preparation Protocols in Frozen-thawed Embryo Transfer in Women With Irregular Cycles|
|Study Start Date :||January 2012|
|Estimated Primary Completion Date :||January 2015|
|Estimated Study Completion Date :||January 2015|
Patients with irregular cycles undergoing FET in reproductive medicine renter of Sun Yat-sen Memorial Hospital will be recruited , who should not be elder than 40 and had more than 3 frozen embryos.They will be randomized to receive the Letrozole and human chorionic gonadotrophin ovulation induced cycles.
Drug: Letrozole and human chorionic gonadotrophin
the follicular development is supported by Letrozole(LE) 2.5mg,once daily is introduced on cycle day 3 .And on cycle day 10 , a Vagina ultrasound is introduced to monitor the development of the follicular ,following by intramuscular gonadotrophin 37.5~75 IU/d until there is a Luteinizing Hormone(LH) surge or ovulation .On the day appearing Luteinizing Hormone surge，patients is always introduced intramuscular human chorionic gonadotrophin(HCG) 10000 IU.If there is sill no Luteinizing Hormone surge when the follicle is 20-24mm ,the ovulation will be induced by HCG.Then the luteum was supported by HCG 2000-2500 IU/3d.Transfer of thawed embryos will be performed 3 days after ovulation is observed.
Patients with irregular cycles undergoing FET in reproductive medicine renter of Sun Yat-sen Memorial Hospital will be recruited, who should not be elder than 40 and had more than 3 frozen embryos will be randomized to receive the estradiol and progesterone replacement therapy cycles.
Drug: estradiol and progesterone
oral estradiol, 2 mg, once daily, was introduced on cycle day 3 with an increasing doses protocol. If the endometrial thickness was greater than 7mm, progesterone 40-60 mg in oil was administered via intramuscular injection. Transfer of thawed embryos was performed 3 days later
- ongoing pregnancy rate [ Time Frame: 12 weeks after pregnancy ]12 weeks after pregnancy,people go Vaginal B ultrasonic examination，being saw gestational sac and heart tube beat as ongoing pregnancy
- pregnancy rate [ Time Frame: 2 weeks after Embryo transplantation ]2 weeks after Embryo transplantation, people go urine HCG and blood HCG test，positive as pregnancy
- clinical pregnancy rate [ Time Frame: 5 weeks after Embryo transplantation ]5 weeks after Embryo transplantation,people go Vaginal B ultrasonic，being saw the gestation sac as clinical pregnancy
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01780610
|Contact: Zhang qixue, professor||13602737433|
|Sun Yat-Sen Memorial Hospital||Recruiting|
|Guangzhou, Guangdong, China, 510000|
|Contact: Zhang qingxue, doctor 13602797433|
|Study Director:||Zhang qingxue, doctor||Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|