A Study:the Different Outcomes Between Natural Cycle and Hormone Replacement Cycle in FET
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01780558|
Recruitment Status : Unknown
Verified March 2013 by Qingxue Zhang, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University.
Recruitment status was: Recruiting
First Posted : January 31, 2013
Last Update Posted : April 2, 2013
|Condition or disease||Intervention/treatment|
|Infertility||Other: natural cycles Drug: estradiol and progesterone|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||600 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||A Randomized Controlled Study:the Different Outcomes Between Natural Cycle and Hormon Replacement Cycle in FET|
|Study Start Date :||January 2010|
|Estimated Primary Completion Date :||January 2015|
|Estimated Study Completion Date :||January 2015|
Patients with regular cycles undergoing FET in reproductive medicine renter of Sun Yat-sen Memorial Hospital will be recruited, who should not be elder than 40 and had more than 3 frozen embryos.They will be randomized to receive the natural cycles.
Other: natural cycles
the ovulation is monitored spontaneously or induced by HCG when the dominant follicle is larger than 18mm without LH surge. Transfer of thawed embryos will be performed 4 days after LH surge/HCG administration or 3 days after ovulation is observed.
Other Name: spontaneous ovulation cycles
Patients with regular cycles undergoing FET in reproductive medicine renter of Sun Yat-sen Memorial Hospitalwill be recruited , who should not be elder than 40 and had more than 3 frozen embryos will be randomized to receive the estradiol and progesterone replacement therapy cycles.
Drug: estradiol and progesterone
oral estradiol, 2 mg, once daily, is introduced on cycle day 3 with an increasing doses protocol. If the endometrial thickness is greater than 7mm, progesterone 40-60 mg in oil will be administered via intramuscular injection. Transfer of thawed embryos will be performed 3 days later.
- Live-birth rate [ Time Frame: Live-birth after FET ]
- pregnancy rate [ Time Frame: 2 weeks after Embryo transplantation ]2 weeks after Embryo transplantation, people go urine HCG and blood HCG test，positive as pregnancy
- clinical pregnancy rate [ Time Frame: 5 weeks after Embryo transplantation ]5 weeks after Embryo transplantation,people go Vaginal B ultrasonic，being saw the gestation sac as clinical pregnancy
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01780558
|Contact: Zhang qixue, firstname.lastname@example.org|
|Sun Yat-Sen Memorial Hospital||Recruiting|
|Guangzhou, Guangdong, China, 510000|
|Contact: Zhang qingxue, doctor 13602797433 email@example.com|
|Study Director:||Zhang qingxue, doctor||Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|