A Study:the Different Outcomes Between Natural Cycle and Hormone Replacement Cycle in FET
|ClinicalTrials.gov Identifier: NCT01780558|
Recruitment Status : Unknown
Verified March 2013 by Qingxue Zhang, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University.
Recruitment status was: Recruiting
First Posted : January 31, 2013
Last Update Posted : April 2, 2013
|Condition or disease||Intervention/treatment||Phase|
|Infertility||Other: natural cycles Drug: estradiol and progesterone||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||600 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||A Randomized Controlled Study:the Different Outcomes Between Natural Cycle and Hormon Replacement Cycle in FET|
|Study Start Date :||January 2010|
|Estimated Primary Completion Date :||January 2015|
|Estimated Study Completion Date :||January 2015|
Patients with regular cycles undergoing FET in reproductive medicine renter of Sun Yat-sen Memorial Hospital will be recruited, who should not be elder than 40 and had more than 3 frozen embryos.They will be randomized to receive the natural cycles.
Other: natural cycles
the ovulation is monitored spontaneously or induced by HCG when the dominant follicle is larger than 18mm without LH surge. Transfer of thawed embryos will be performed 4 days after LH surge/HCG administration or 3 days after ovulation is observed.
Other Name: spontaneous ovulation cycles
Patients with regular cycles undergoing FET in reproductive medicine renter of Sun Yat-sen Memorial Hospitalwill be recruited , who should not be elder than 40 and had more than 3 frozen embryos will be randomized to receive the estradiol and progesterone replacement therapy cycles.
Drug: estradiol and progesterone
oral estradiol, 2 mg, once daily, is introduced on cycle day 3 with an increasing doses protocol. If the endometrial thickness is greater than 7mm, progesterone 40-60 mg in oil will be administered via intramuscular injection. Transfer of thawed embryos will be performed 3 days later.
- Live-birth rate [ Time Frame: Live-birth after FET ]
- pregnancy rate [ Time Frame: 2 weeks after Embryo transplantation ]2 weeks after Embryo transplantation, people go urine HCG and blood HCG test，positive as pregnancy
- clinical pregnancy rate [ Time Frame: 5 weeks after Embryo transplantation ]5 weeks after Embryo transplantation,people go Vaginal B ultrasonic，being saw the gestation sac as clinical pregnancy
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01780558
|Contact: Zhang qixue, firstname.lastname@example.org|
|Sun Yat-Sen Memorial Hospital||Recruiting|
|Guangzhou, Guangdong, China, 510000|
|Contact: Zhang qingxue, doctor 13602797433 email@example.com|
|Study Director:||Zhang qingxue, doctor||Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|