The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01780363
Recruitment Status : Completed
First Posted : January 31, 2013
Last Update Posted : January 31, 2013
Information provided by (Responsible Party):
Didem Arslan Tas, Cukurova University

Brief Summary:
Background: Genetics is suggested to play a critical role in the development of Behçet's disease (BD). Shared phenotypic features requires an approach to the differential diagnosis from periodic febrile syndromes particularly from mevalonate kinase deficiency related diseases. We planned to study for evaluating the frequency of mutations and their clinical significance in mevalonate kinase gene in Turkish patients with Behçet's disease.

Condition or disease
Behçet's Disease

Study Type : Observational
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : January 2011
Actual Primary Completion Date : December 2011

frequency of mevalonate kinase gene frequency
Behçet patients
frequency of mevalonate kinase gene mutations

Primary Outcome Measures :
  1. Frequency of mevalonate kinase frequency in Behçet disease [ Time Frame: One year ]

Secondary Outcome Measures :
  1. Mevalonate kinase gene and clinical correlations in Behçet's disease [ Time Frame: One year ]

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Turkish kindred

Inclusion Criteria:

  • Behçet patients

Exclusion Criteria:

  • Diagnosis of periodic fever syndromes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01780363

Cukurova University
Adana, Turkey, 01330
Didem Arslan Tas
Adana, Turkey, 01330
Sponsors and Collaborators
Cukurova University

Responsible Party: Didem Arslan Tas, MD, Cukurova University Identifier: NCT01780363     History of Changes
Other Study ID Numbers: BH-MVK
CUTFBAP25011138 ( Other Identifier: CUTF )
CUTFBAP2501201138 ( Other Identifier: CUTFBAP )
First Posted: January 31, 2013    Key Record Dates
Last Update Posted: January 31, 2013
Last Verified: January 2011

Additional relevant MeSH terms:
Behcet Syndrome
Mouth Diseases
Stomatognathic Diseases
Uveal Diseases
Eye Diseases
Vascular Diseases
Cardiovascular Diseases
Hereditary Autoinflammatory Diseases
Genetic Diseases, Inborn
Skin Diseases, Genetic
Skin Diseases
Skin Diseases, Vascular
Uveitis, Anterior