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MEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASE

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01780363
First Posted: January 31, 2013
Last Update Posted: January 31, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Didem Arslan Tas, Cukurova University
  Purpose
Background: Genetics is suggested to play a critical role in the development of Behçet's disease (BD). Shared phenotypic features requires an approach to the differential diagnosis from periodic febrile syndromes particularly from mevalonate kinase deficiency related diseases. We planned to study for evaluating the frequency of mutations and their clinical significance in mevalonate kinase gene in Turkish patients with Behçet's disease.

Condition
Behçet's Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Didem Arslan Tas, Cukurova University:

Primary Outcome Measures:
  • Frequency of mevalonate kinase frequency in Behçet disease [ Time Frame: One year ]

Secondary Outcome Measures:
  • Mevalonate kinase gene and clinical correlations in Behçet's disease [ Time Frame: One year ]

Study Start Date: January 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
controls
frequency of mevalonate kinase gene frequency
Behçet patients
frequency of mevalonate kinase gene mutations

  Eligibility

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Turkish kindred
Criteria

Inclusion Criteria:

  • Behçet patients

Exclusion Criteria:

  • Diagnosis of periodic fever syndromes
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01780363


Locations
Turkey
Cukurova University
Adana, Turkey, 01330
Didem Arslan Tas
Adana, Turkey, 01330
Sponsors and Collaborators
Cukurova University
  More Information

Responsible Party: Didem Arslan Tas, MD, Cukurova University
ClinicalTrials.gov Identifier: NCT01780363     History of Changes
Other Study ID Numbers: BH-MVK
CUTFBAP25011138 ( Other Identifier: CUTF )
CUTFBAP2501201138 ( Other Identifier: CUTFBAP )
First Submitted: January 29, 2013
First Posted: January 31, 2013
Last Update Posted: January 31, 2013
Last Verified: January 2011

Additional relevant MeSH terms:
Behcet Syndrome
Mouth Diseases
Stomatognathic Diseases
Uveitis, Anterior
Panuveitis
Uveitis
Uveal Diseases
Eye Diseases
Vasculitis
Vascular Diseases
Cardiovascular Diseases
Hereditary Autoinflammatory Diseases
Genetic Diseases, Inborn
Skin Diseases, Genetic
Skin Diseases
Skin Diseases, Vascular